EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.5.13 | expressed in HEK-293T cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.5.13 | DELTA-exon9 | the mutation leads to severely reduced enzyme activity and is associated with L-2-hydroxyglutaric aciduria | Homo sapiens |
1.1.5.13 | E176D | the mutation leads to severely reduced enzyme activity and is associated with L-2-hydroxyglutaric aciduria | Homo sapiens |
1.1.5.13 | K81E | the mutation leads to severely reduced enzyme activity and is associated with L-2-hydroxyglutaric aciduria | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.5.13 | D-2-hydroxyglutarate | - |
Homo sapiens | |
1.1.5.13 | additional information | the activity is not affected by 0.01 mM Co2+, 0.01 mM Zn2+, or 1 mM EDTA | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.5.13 | 0.8 | - |
L-2-hydroxyglutarate | in the absence of FAD, pH and temperature not specified in the publication | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.5.13 | mitochondrial membrane | - |
Homo sapiens | 31966 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.5.13 | L-2-hydroxyglutarate + a quinone | Homo sapiens | - |
2-oxoglutarate + a quinol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.5.13 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.5.13 | L-2-hydroxyglutarate + a quinone | - |
Homo sapiens | 2-oxoglutarate + a quinol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.5.13 | ? | x * 45000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.5.13 | L-2-hydroxyglutarate dehydrogenase | - |
Homo sapiens |
1.1.5.13 | lhgO | - |
Homo sapiens |
1.1.5.13 | YgaF | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.5.13 | FAD | dependent on | Homo sapiens | |
1.1.5.13 | additional information | not stimulated by FMN | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.5.13 | malfunction | enzyme mutations cause L-2-hydroxyglutaric aciduria | Homo sapiens |