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Literature summary extracted from

  • Sribney, M.
    Enzymatic synthesis of ceramide (1966), Biochim. Biophys. Acta, 125, 542-547 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 Ca2+
-
 Cavia porcellus
2.3.1.24 Ca2+
-
 Gallus gallus
2.3.1.24 Mn2+
-
 Cavia porcellus
2.3.1.24 Mn2+
-
 Gallus gallus
2.3.1.297 Ca2+
-
 Cavia porcellus
2.3.1.297 Ca2+
-
 Gallus gallus
2.3.1.297 Mn2+
-
 Cavia porcellus
2.3.1.297 Mn2+
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.24 microsome
-
 Gallus gallus
-
-
2.3.1.24 microsome
-
 Cavia porcellus
-
-
2.3.1.297 microsome
-
 Gallus gallus
-
-
2.3.1.297 microsome
-
 Cavia porcellus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.24 Mg2+ no absolute requirement for metal ions, magnesium ions stimulate the reaction Gallus gallus
2.3.1.24 Mg2+ no absolute requirement for metal ions, magnesium ions stimulate the reaction Cavia porcellus
2.3.1.297 Mg2+ no absolute requirement for metal ions, magnesium ions stimulate the reaction Gallus gallus
2.3.1.297 Mg2+ no absolute requirement for metal ions, magnesium ions stimulate the reaction Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Cavia porcellus
-
-
-
2.3.1.24 Gallus gallus
-
-
-
2.3.1.297 Cavia porcellus
-
-
-
2.3.1.297 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.24 brain
-
 Cavia porcellus
-
2.3.1.24 liver
-
 Gallus gallus
-
2.3.1.297 brain
-
 Cavia porcellus
-
2.3.1.297 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 DL-erythro-sphingosine + palmitoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is slightly preferred Cavia porcellus N-palmitoyl-DL-sphingosine + CoA
-
 ?
2.3.1.24 DL-erythro-sphingosine + palmitoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Gallus gallus N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 DL-threo-sphingosine + palmitoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is slightly preferred Cavia porcellus N-palmitoyl-DL-sphingosine + CoA
-
 ?
2.3.1.24 DL-threo-sphingosine + palmitoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Gallus gallus N-palmitoylsphingosine + CoA
-
 ?
2.3.1.297 DL-erythro-sphingosine + nervonoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Gallus gallus N-nervonoylsphingosine + CoA
-
 ?
2.3.1.297 DL-erythro-sphingosine + nervonoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Cavia porcellus N-nervonoylsphingosine + CoA
-
 ?
2.3.1.297 DL-threo-sphingosine + nervonoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Gallus gallus N-nervonoylsphingosine + CoA
-
 ?
2.3.1.297 DL-threo-sphingosine + nervonoyl-CoA both the threo and erythro isomers are active as acceptors, the latter is preferred Cavia porcellus N-nervonoylsphingosine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 acyl-CoA : sphingosine N-acyltramferase
-
 Gallus gallus
2.3.1.24 acyl-CoA : sphingosine N-acyltramferase
-
 Cavia porcellus
2.3.1.297 acyl-CoA : sphingosine N-acyltramferase
-
 Gallus gallus
2.3.1.297 acyl-CoA : sphingosine N-acyltramferase
-
 Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.24 7.5
-
-
 Gallus gallus
2.3.1.24 7.5
-
-
 Cavia porcellus
2.3.1.297 7.5
-
-
 Gallus gallus
2.3.1.297 7.5
-
-
 Cavia porcellus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.24 6.5 8.2 about 50% of maximal activity within this range Gallus gallus
2.3.1.24 6.5 8.2 about 50% of maximal activity within this range Cavia porcellus
2.3.1.297 6.5 8.2 about 50% of maximal activity within this range Gallus gallus
2.3.1.297 6.5 8.2 about 50% of maximal activity within this range Cavia porcellus