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Literature summary extracted from

  • Zhong, W.; Jeffries, M.W.; Georgopapadakou, N.H.
    Inhibition of inositol phosphorylceramide synthase by aureobasidin A in Candida and Aspergillus species (2000), Antimicrob. Agents Chemother., 44, 651-653 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.227 aureobasidin A IC50 value 2.6 ng/ml. Strain is intrinsically resistant to aureobasidin A (MIC above 50 microg/ml), but has IPC synthase activity sensitive to aureobasidin A Aspergillus flavus
2.7.1.227 aureobasidin A IC50 value 2.1 ng/ml. All Candida species tested are well susceptible to aureobasidin A with MICs below 2 microg/ml Candida albicans
2.7.1.227 aureobasidin A IC50 value 3.4 ng/ml. All Candida species tested are well susceptible to aureobasidin A with MICs below 2 microg/ml Candida tropicalis
2.7.1.227 aureobasidin A IC50 value 2.5 ng/ml. All Candida species tested are well susceptible to aureobasidin A with MICs below 2 microg/ml Nakaseomyces glabratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.227 microsome
-
 Candida albicans
-
-
2.7.1.227 microsome
-
 Candida tropicalis
-
-
2.7.1.227 microsome
-
 Nakaseomyces glabratus
-
-
2.7.1.227 microsome
-
 Aspergillus flavus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.227 Aspergillus flavus
-
-
-
2.7.1.227 Aspergillus flavus ATCC 9643
-
-
-
2.7.1.227 Candida albicans
-
-
-
2.7.1.227 Candida albicans ATCC 90028
-
-
-
2.7.1.227 Candida tropicalis
-
-
-
2.7.1.227 Candida tropicalis ATCC 750
-
-
-
2.7.1.227 Nakaseomyces glabratus
-
-
-
2.7.1.227 Nakaseomyces glabratus ATCC 90030
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.227 6.1
-
 pH not specified in the publication, temperature not specified in the publication Aspergillus flavus
2.7.1.227 134
-
 pH not specified in the publication, temperature not specified in the publication Candida albicans
2.7.1.227 211
-
 pH not specified in the publication, temperature not specified in the publication Nakaseomyces glabratus
2.7.1.227 333
-
 pH not specified in the publication, temperature not specified in the publication Candida tropicalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Candida albicans ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Candida tropicalis ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Nakaseomyces glabratus ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Aspergillus flavus ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Candida albicans ATCC 90028 ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Candida tropicalis ATCC 750 ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Nakaseomyces glabratus ATCC 90030 ?
-
 ?
2.7.1.227 1-phosphatidyl-1D-myo-inositol + N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine
-
 Aspergillus flavus ATCC 9643 ?
-
 ?