Literature summary extracted from

Del Bel, L.M.; Brill, J.A.
Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport (2018), Traffic, 19, 301-318 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.3.B4	endosome	-	Drosophila melanogaster	5768	-
3.1.3.B4	endosome	-	Saccharomyces cerevisiae	5768	-
3.1.3.B4	Golgi apparatus	-	Drosophila melanogaster	5794	-
3.1.3.B4	Golgi apparatus	-	Saccharomyces cerevisiae	5794	-
3.1.3.B4	membrane	an integral membrane protein	Drosophila melanogaster	16020	-
3.1.3.B4	membrane	an integral membrane protein	Saccharomyces cerevisiae	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.B4	phosphatidylinositol 4-phosphate + H2O	Drosophila melanogaster	-	phosphatidylinositol + phosphate	-	?
3.1.3.B4	phosphatidylinositol 4-phosphate + H2O	Saccharomyces cerevisiae	-	phosphatidylinositol + phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.B4	Drosophila melanogaster	-	-	-
3.1.3.B4	Saccharomyces cerevisiae	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.B4	central nervous system	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.B4	phosphatidylinositol 4-phosphate + H2O	-	Drosophila melanogaster	phosphatidylinositol + phosphate	-	?
3.1.3.B4	phosphatidylinositol 4-phosphate + H2O	-	Saccharomyces cerevisiae	phosphatidylinositol + phosphate	-	?
3.1.3.B4	phosphatidylinositol 4-phosphate + H2O	preferred substrate	Saccharomyces cerevisiae	phosphatidylinositol + phosphate	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.1.3.B4	?	x * 65000, SDS-PAGE	Saccharomyces cerevisiae

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.3.B4	INPP5f	-	Drosophila melanogaster
3.1.3.B4	INPP5f	-	Saccharomyces cerevisiae
3.1.3.B4	PI 4-phosphatase	-	Drosophila melanogaster
3.1.3.B4	PI 4-phosphatase	-	Saccharomyces cerevisiae
3.1.3.B4	Sac1	-	Drosophila melanogaster
3.1.3.B4	Sac1	-	Saccharomyces cerevisiae

General Information

EC Number	General Information	Comment	Organism
3.1.3.B4	physiological function	in Drosophila development, the enzyme regulates JNK signaling, attenuates Hedgehog signaling, and regulates axon guidance in the embryonic central nervous system. The enzyme is required for postembryonic synaptic maturation and neuronal cell maintenance	Drosophila melanogaster

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Release 2023.1 (January 2023)