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Literature summary extracted from
- Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation (2015), Toxins, 7, 1457-1466 .
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.41 | lysophosphatidylcholine + H2O | Corynebacterium ulcerans | - |
lysophosphatidic acid + choline | - |
ir |  |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Corynebacterium pseudotuberculosis | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles reclusa | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Arcanobacterium haemolyticum | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles laeta | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles intermedia | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles arizonica | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles gaucho | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Loxosceles rufescens | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | Photobacterium damselae subsp. damselae | - |
lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | additional information | Corynebacterium ulcerans | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Corynebacterium pseudotuberculosis | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles reclusa | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Arcanobacterium haemolyticum | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles laeta | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles intermedia | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles arizonica | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles gaucho | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Loxosceles rufescens | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | additional information | Photobacterium damselae subsp. damselae | no activity with phosphatidylcholine | ? | - |
? | |
| 3.1.4.41 | sphingomyelin + H2O | Corynebacterium ulcerans | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Corynebacterium pseudotuberculosis | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles reclusa | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Arcanobacterium haemolyticum | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles laeta | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles intermedia | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles arizonica | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles gaucho | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Loxosceles rufescens | - |
ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | Photobacterium damselae subsp. damselae | - |
ceramide 1-phosphate + choline | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.41 | Arcanobacterium haemolyticum | - |
- |
- |
| 3.1.4.41 | Corynebacterium pseudotuberculosis | - |
- |
- |
| 3.1.4.41 | Corynebacterium ulcerans | - |
- |
- |
| 3.1.4.41 | Loxosceles arizonica | - |
- |
- |
| 3.1.4.41 | Loxosceles gaucho | - |
- |
- |
| 3.1.4.41 | Loxosceles intermedia | - |
- |
- |
| 3.1.4.41 | Loxosceles laeta | - |
- |
- |
| 3.1.4.41 | Loxosceles reclusa | - |
- |
- |
| 3.1.4.41 | Loxosceles rufescens | - |
- |
- |
| 3.1.4.41 | Photobacterium damselae subsp. damselae | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.41 | venom | - |
Loxosceles reclusa | - |
| 3.1.4.41 | venom | - |
Loxosceles laeta | - |
| 3.1.4.41 | venom | - |
Loxosceles intermedia | - |
| 3.1.4.41 | venom | - |
Loxosceles arizonica | - |
| 3.1.4.41 | venom | - |
Loxosceles gaucho | - |
| 3.1.4.41 | venom | - |
Loxosceles rufescens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Corynebacterium ulcerans | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Corynebacterium pseudotuberculosis | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles reclusa | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Arcanobacterium haemolyticum | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles laeta | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles intermedia | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles arizonica | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles gaucho | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Loxosceles rufescens | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | lysophosphatidylcholine + H2O | - |
Photobacterium damselae subsp. damselae | lysophosphatidic acid + choline | - |
ir | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Corynebacterium ulcerans | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Corynebacterium pseudotuberculosis | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles reclusa | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Arcanobacterium haemolyticum | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles laeta | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles intermedia | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles arizonica | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles gaucho | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Loxosceles rufescens | ? | - |
? | |
| 3.1.4.41 | additional information | no activity with phosphatidylcholine | Photobacterium damselae subsp. damselae | ? | - |
? | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Corynebacterium ulcerans | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Corynebacterium pseudotuberculosis | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles reclusa | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Arcanobacterium haemolyticum | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles laeta | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles intermedia | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles arizonica | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles gaucho | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles rufescens | ceramide 1-phosphate + choline | - |
ir | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Photobacterium damselae subsp. damselae | ceramide 1-phosphate + choline | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.41 | SMase D | - |
Corynebacterium ulcerans |
| 3.1.4.41 | SMase D | - |
Corynebacterium pseudotuberculosis |
| 3.1.4.41 | SMase D | - |
Loxosceles reclusa |
| 3.1.4.41 | SMase D | - |
Arcanobacterium haemolyticum |
| 3.1.4.41 | SMase D | - |
Loxosceles laeta |
| 3.1.4.41 | SMase D | - |
Loxosceles intermedia |
| 3.1.4.41 | SMase D | - |
Loxosceles arizonica |
| 3.1.4.41 | SMase D | - |
Loxosceles gaucho |
| 3.1.4.41 | SMase D | - |
Loxosceles rufescens |
| 3.1.4.41 | SMase D | - |
Photobacterium damselae subsp. damselae |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Corynebacterium ulcerans |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Corynebacterium pseudotuberculosis |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles reclusa |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Arcanobacterium haemolyticum |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles laeta |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles intermedia |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles arizonica |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles gaucho |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Loxosceles rufescens |
| 3.1.4.41 | physiological function | the reaction products of the enzyme promote cell migration and inflammation | Photobacterium damselae subsp. damselae |
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