BRENDA - Enzyme Database

The effects of promoter variations of the N-methylcanadine 1-hydroxylase (CYP82Y1) gene on the noscapine production in opium poppy

Abedini, D.; Monfared, S.R.; Abbasi, A.; Sci. Rep. 8, 4973 (2018) View publication on PubMedView publication on EuropePMC

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
Papaver bracteatum
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.14.14.166
Papaver bracteatum
-
-
-
1.14.14.166
Papaver somniferum
I3PLR1
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.166
leaf
-
Papaver somniferum
-
1.14.14.166
leaf
expression is lower than in Papaver somniferum
Papaver bracteatum
-
1.14.14.166
seed
-
Papaver somniferum
-
1.14.14.166
stem
-
Papaver somniferum
-
1.14.14.166
stem
expression is lower than in Papaver somniferum
Papaver bracteatum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
752243
Papaver bracteatum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
752243
Papaver somniferum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
752243
Papaver bracteatum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
752243
Papaver somniferum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.14.14.166
CYP82Y1
-
Papaver somniferum
1.14.14.166
N-methylcanadine 1-hydroxylase
-
Papaver bracteatum
1.14.14.166
N-methylcanadine 1-hydroxylase
-
Papaver somniferum
1.14.14.166
PbCYP82Y1
-
Papaver bracteatum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
Papaver bracteatum
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.166
leaf
-
Papaver somniferum
-
1.14.14.166
leaf
expression is lower than in Papaver somniferum
Papaver bracteatum
-
1.14.14.166
seed
-
Papaver somniferum
-
1.14.14.166
stem
-
Papaver somniferum
-
1.14.14.166
stem
expression is lower than in Papaver somniferum
Papaver bracteatum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
752243
Papaver bracteatum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
-
752243
Papaver somniferum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
752243
Papaver bracteatum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.166
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
752243
Papaver somniferum
(S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.14.14.166
Papaver somniferum
an SSR (Simple Sequence Repeats) is embedded in the promoter region of the CYP82Y1 gene. Quantitative PCR shows that a variation in the motif repeat number (either a decrease or increase) down-regulates the expression of the CYP82Y1 gene
down
General Information
EC Number
General Information
Commentary
Organism
1.14.14.166
metabolism
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
Papaver bracteatum
1.14.14.166
metabolism
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
Papaver somniferum
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.14.14.166
metabolism
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
Papaver bracteatum
1.14.14.166
metabolism
the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine
Papaver somniferum
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.14.14.166
Papaver somniferum
an SSR (Simple Sequence Repeats) is embedded in the promoter region of the CYP82Y1 gene. Quantitative PCR shows that a variation in the motif repeat number (either a decrease or increase) down-regulates the expression of the CYP82Y1 gene
down