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Literature summary extracted from

  • Landry, J.; Sutton, A.; Tafrov, S.T.; Heller, R.C.; Stebbins, J.; Pillus, L.; Sternglanz, R.
    The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases (2000), Proc. Natl. Acad. Sci. USA, 97, 5807-5811 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.286 expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.286 nicotinamide
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.286 His bind affinity resin column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [histone H4]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 HST2
-
 Saccharomyces cerevisiae
2.3.1.286 NAD-dependent protein deacetylase
-
 Saccharomyces cerevisiae
2.3.1.286 silent information regulator 2
-
 Saccharomyces cerevisiae
2.3.1.286 Sir2
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Saccharomyces cerevisiae