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Literature summary extracted from

  • Park, M.; Chen, X.; Lang, D.; Ng, K.; Facchini, P.
    Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy (2018), Plant J., 95, 252-267 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.352 expression in Escherichia coli Papaver somniferum

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.352 S122Y profound negative effects on dimerization and activity Papaver somniferum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.352 S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine Papaver somniferum this activity is part of the noscapine biosynthesis pathway S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.352 Papaver somniferum I3PLQ6 I3PLQ6: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT2, I3PLQ7: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT3
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3.1.1.105 Papaver somniferum
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.352 S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine this activity is part of the noscapine biosynthesis pathway Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
-
 ?
2.1.1.352 S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine 3-O-acetyl-4'-O-demethylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-hydroxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde. 3-O-Acetylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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 ?
3.1.1.105 3-O-acetylpapaveroxine + H2O
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 Papaver somniferum narcotine hemiacetal + acetate
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 ?
3.1.1.105 4'-O-demethyl-3-O-acetylpapaveroxine + H2O
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 Papaver somniferum narcotoline hemiacetal + acetate
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 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.352 heterodimer complex of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes. 6OMT shares 81% amino acid sequence identity with OMT3 Papaver somniferum

General Information

EC Number General Information Comment Organism
2.1.1.352 metabolism this activity is part of the noscapine biosynthesis pathway Papaver somniferum