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Literature summary extracted from

  • Kim, R.J.; Kim, H.J.; Shim, D.; Suh, M.C.
    Molecular and biochemical characterizations of the monoacylglycerol lipase gene family of Arabidopsis thaliana (2016), Plant J., 85, 758-771 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.23 recombinant expression of C-terminally eYFP-tagged enzyme tobacco epidermal cells or protoplast cells Arabidopsis thaliana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.23 0.15
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL8 Arabidopsis thaliana
3.1.1.23 0.16
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL15 Arabidopsis thaliana
3.1.1.23 0.16
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL6 Arabidopsis thaliana
3.1.1.23 0.17
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL1 Arabidopsis thaliana
3.1.1.23 0.17
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL10 Arabidopsis thaliana
3.1.1.23 0.17
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL9 Arabidopsis thaliana
3.1.1.23 0.2 0.25 monoacylglycerol pH 8.0, 30°C, AtMAGL2 Arabidopsis thaliana
3.1.1.23 0.2 0.25 monoacylglycerol pH 8.0, 30°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.2 0.25 monoacylglycerol pH 8.0, 30°C, AtMAGL7 Arabidopsis thaliana
3.1.1.23 0.22
-
 lysophosphatidylethanolamine pH 8.0, 30°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.24
-
 lysophosphatidylethanolamine pH 8.0, 30°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.25
-
 lysophosphatidylcholine pH 8.0, 30°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.28
-
 lysophosphatidylethanolamine pH 8.0, 30°C, AtMAGL1 Arabidopsis thaliana
3.1.1.23 0.3
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL14 Arabidopsis thaliana
3.1.1.23 0.3
-
 monoacylglycerol pH 8.0, 30°C, AtMAGL16 Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.23 cytosol
-
 Arabidopsis thaliana 5829
-
3.1.1.23 endoplasmic reticulum
-
 Arabidopsis thaliana 5783
-
3.1.1.23 Golgi apparatus
-
 Arabidopsis thaliana 5794
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Arabidopsis thaliana
-
-
-
3.1.1.23 Arabidopsis thaliana O23179
-
-
3.1.1.23 Arabidopsis thaliana O23180
-
-
3.1.1.23 Arabidopsis thaliana O23181
-
-
3.1.1.23 Arabidopsis thaliana O48723
-
-
3.1.1.23 Arabidopsis thaliana O49284
-
-
3.1.1.23 Arabidopsis thaliana O80959
-
-
3.1.1.23 Arabidopsis thaliana Q8H133
-
-
3.1.1.23 Arabidopsis thaliana Q93ZQ3
-
-
3.1.1.23 Arabidopsis thaliana Q9FIY1
-
-
3.1.1.23 Arabidopsis thaliana Q9SV43
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.23 0.07
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 Arabidopsis thaliana
3.1.1.23 0.08
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.09
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 Arabidopsis thaliana
3.1.1.23 0.14
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL10 Arabidopsis thaliana
3.1.1.23 0.16
-
 lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL1 Arabidopsis thaliana
3.1.1.23 0.17
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 Arabidopsis thaliana
3.1.1.23 0.2
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL9 Arabidopsis thaliana
3.1.1.23 0.33
-
 lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL2 Arabidopsis thaliana
3.1.1.23 0.38
-
 lysophosphatidylcholine, pH 8.0, 38°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.41
-
 lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL4 Arabidopsis thaliana
3.1.1.23 0.52
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL1 Arabidopsis thaliana
3.1.1.23 0.63
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL2 Arabidopsis thaliana
3.1.1.23 1.77
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL7 Arabidopsis thaliana
3.1.1.23 12.11
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL8 Arabidopsis thaliana
3.1.1.23 23.93
-
 monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL6 Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 lysophosphatidylcholine + H2O
-
 Arabidopsis thaliana fatty acid + glycerophosphocholine
-
 ?
3.1.1.23 lysophosphatidylethanolamine + H2O
-
 Arabidopsis thaliana fatty acid + glycerophosphoethanolamine
-
 ?
3.1.1.23 monoacylglycerol + H2O
-
 Arabidopsis thaliana fatty acid + glycerol
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL1 is active with monoacylglycerol and lysophosphatidylethanolamine substrates, but not with diacylglycerol, triacylglycerol, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL10 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL11 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL14 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL15 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL16 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL2 is active with monoacylglycerol and lysophosphatidylethanolamine substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylcholine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL3 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL4 is active with monoacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates, but not with diacylglycerol, and triacylglycerol substrates as well as with monogalactosyldiacylglycerol and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL5 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL6 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL7 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL8 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?
3.1.1.23 additional information usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL9 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview Arabidopsis thaliana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 AtMAGL
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL1
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL10
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL11
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL14
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL15
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL16
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL2
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL3
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL4
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL5
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL6
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL7
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL8
-
 Arabidopsis thaliana
3.1.1.23 AtMAGL9
-
 Arabidopsis thaliana
3.1.1.23 MAGL
-
 Arabidopsis thaliana
3.1.1.23 monoacylglycerol lipase
-
 Arabidopsis thaliana
3.1.1.23 patatin-like protein 1 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 2 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 3 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 4 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 5 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 6 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 7 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 8 UniProt Arabidopsis thaliana
3.1.1.23 patatin-like protein 9 UniProt Arabidopsis thaliana
3.1.1.23 PLP1
-
 Arabidopsis thaliana
3.1.1.23 PLP2
-
 Arabidopsis thaliana
3.1.1.23 PLP3
-
 Arabidopsis thaliana
3.1.1.23 PLP4
-
 Arabidopsis thaliana
3.1.1.23 PLP5
-
 Arabidopsis thaliana
3.1.1.23 PLP6
-
 Arabidopsis thaliana
3.1.1.23 PLP7
-
 Arabidopsis thaliana
3.1.1.23 PLP8
-
 Arabidopsis thaliana
3.1.1.23 PLP9
-
 Arabidopsis thaliana

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.23 30
-
 assay at Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.23 8
-
 assay at Arabidopsis thaliana
3.1.1.23 8 9
-
 Arabidopsis thaliana

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.1.23 6 9.5 activity range, profile overview Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
3.1.1.23 metabolism monoacylglycerol lipases (MAGLs) catalyze the last step of triacylglycerol breakdown, which is the hydrolysis of monoacylglycerol (MAG) to fatty acid and glycerol Arabidopsis thaliana
3.1.1.23 additional information computational three-dimensional structure modeling Arabidopsis thaliana
3.1.1.23 additional information computational three-dimensional structure modeling. Comparison of three dimensional protein models between Arabidopsis monoacylglycerol lipase (AtMAGL8) and the human protein Arabidopsis thaliana
3.1.1.23 physiological function monoacylglycerol lipases (MAGLs) catalyze the last step of triacylglycerol breakdown, which is the hydrolysis of monoacylglycerol (MAG) to fatty acid and glycerol Arabidopsis thaliana