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Literature summary extracted from

  • Dickie, E.A.; Young, S.A.; Smith, T.K.
    Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei (2018), Parasitology, 146, 604-616 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expressed in Escherichia coli BL21/pLysSGold cells Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 ceramide 1-phosphate + H2O
-
 Trypanosoma brucei ?
-
 ?
3.1.4.12 lyso-phosphatidylcholine + H2O
-
 Trypanosoma brucei ?
-
 ?
3.1.4.12 additional information the enzyme is inactive towards sphingosine 1-phosphate and phosphatidylcholine Trypanosoma brucei ?
-
 ?
3.1.4.12 sphingomyelin + H2O the enzyme is active towards sphingomyelin species with a range of fatty acid chain lengths (C16-C24) Trypanosoma brucei ceramide + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase
-
 Trypanosoma brucei
3.1.4.12 nSMase
-
 Trypanosoma brucei