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Literature summary extracted from

  • Zhou, L.; Shang, M.; Shi, M.; Zhao, L.; Lin, Z.; Chen, T.; Wu, Y.; Tang, Z.; Sun, H.; Yu, J.; Huang, Y.; Yu, X.
    Clonorchis sinensis lysophospholipase inhibits TGF-beta1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2 (2016), Parasitol. Res., 115, 643-650 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.5 2-lysophosphatidylcholine + H2O Clonorchis sinensis
-
glycerophosphocholine + a carboxylate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.5 Clonorchis sinensis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.5 2-lysophosphatidylcholine + H2O
-
Clonorchis sinensis glycerophosphocholine + a carboxylate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.1.5 ? x * 25000, SDS-PAGE Clonorchis sinensis

Synonyms

EC Number Synonyms Comment Organism
3.1.1.5 lysophospholipase A
-
Clonorchis sinensis
3.1.1.5 lysoPLA
-
Clonorchis sinensis

General Information

EC Number General Information Comment Organism
3.1.1.5 physiological function the enzyme can attenuate the fibrogenic response by inhibiting activation of LX-2 cells, thereby balancing the pro-fibrotic and anti-fibrotic response during the Clonochis sinensis infection. The enzyme inhibits the phosphorylations of Smad3, JNK, and ERK in response to transforming growth factor-beta1 in LX-2 cells Clonorchis sinensis