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Literature summary extracted from

  • Zhou, L.; Shi, M.; Zhao, L.; Lin, Z.; Tang, Z.; Sun, H.; Chen, T.; Lv, Z.; Xu, J.; Huang, Y.; Yu, X.
    Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis (2017), Parasit. Vectors, 10, 295 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.5 expressed in Escherichia coli BL21(DE3) cells Clonorchis sinensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.5 2-lysophosphatidylcholine + H2O Clonorchis sinensis
-
 glycerophosphocholine + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.5 Clonorchis sinensis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.5 His Bind Purification Kit Clonorchis sinensis

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.5 2-lysophosphatidylcholine + H2O
-
 Clonorchis sinensis glycerophosphocholine + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.5 lysophospholipase A
-
 Clonorchis sinensis
3.1.1.5 lysoPLA
-
 Clonorchis sinensis

General Information

EC Number General Information Comment Organism
3.1.1.5 physiological function treating RAW264.7 cells with the enzyme significantly induces interleukin-25 expression. The enzyme activates hepatic stellate cells by upregulating interleukin-25 in macrophages through the protein kinase A-dependent B-Raf/ERK1/2 pathway and potentially promotes hepatic fibrosis during Clonorchis sinensis infection Clonorchis sinensis