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Literature summary extracted from

  • Li, L.; Wang, F.; Yan, P.; Jing, W.; Zhang, C.; Kudla, J.; Zhang, W.
    A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca2+ signals and confers salt tolerance to rice (2017), New Phytol., 214, 1172-1187 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.11 expressed as glutathione S-transferase-tagged protein in Escherichia coli Oryza sativa Japonica Group

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.11 D161R the mutant shows 10% and 5% hydrolyzing activity for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and 1-phosphatidyl-1D-myo-inositol 4-phosphate, respectively, compared to the wild type enzyme Oryza sativa Japonica Group
3.1.4.11 H129A the mutant shows less than 22% and 6% hydrolyzing activity for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and 1-phosphatidyl-1D-myo-inositol 4-phosphate, respectively, compared to the wild type enzyme Oryza sativa Japonica Group

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 EGTA
-
 Oryza sativa Japonica Group

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.11 cytosol
-
 Oryza sativa Japonica Group 5829
-
3.1.4.11 plasma membrane
-
 Oryza sativa Japonica Group 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ maximum activity at 0.1 mM Ca2+ Oryza sativa Japonica Group

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Oryza sativa Japonica Group
-
 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O Oryza sativa Japonica Group preferred substrate. With 1-phosphatidyl-1D-myo-inositol 4-phosphate, the enzyme displays a more than 3fold higher hydrolyzing activity compared to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Oryza sativa Japonica Group
-
 cultivar Nipponbare
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 shoot
-
 Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Oryza sativa Japonica Group 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O preferred substrate Oryza sativa Japonica Group 1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
 ?
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O preferred substrate. With 1-phosphatidyl-1D-myo-inositol 4-phosphate, the enzyme displays a more than 3fold higher hydrolyzing activity compared to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Oryza sativa Japonica Group 1D-myo-inositol 1,4-bisphosphate + diacylglycerol
-
 ?
3.1.4.11 additional information the enzyme displays scarcely any activity towards 1-phosphatidyl-1D-myo-inositol or phosphatidylcholine Oryza sativa Japonica Group ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phosphoinositide-specific phospholipase C
-
 Oryza sativa Japonica Group
3.1.4.11 PI-PLC
-
 Oryza sativa Japonica Group
3.1.4.11 PLC1
-
 Oryza sativa Japonica Group

General Information

EC Number General Information Comment Organism
3.1.4.11 malfunction loss of enzyme function renders rice plants salt sensitive Oryza sativa Japonica Group
3.1.4.11 physiological function the enzyme elicits stress-induced Ca2+ signals regulating salt tolerance in rice. Enzyme-mediated Ca2+ signaling is essential for controlling Na+ accumulation in leaf blades, thus establishing whole plant salt tolerance Oryza sativa Japonica Group