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Literature summary extracted from

  • Wang, C.; Aleksandrov, A.A.; Yang, Z.; Forouhar, F.; Proctor, E.A.; Kota, P.; An, J.; Kaplan, A.; Khazanov, N.; Boel, G.; Stockwell, B.R.; Senderowitz, H.; Dokholyan, N.V.; Riordan, J.R.; Brouillette, C.G.; Hunt, J.F.
    Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (2018), J. Biol. Chem., 293, 17685-17704 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.6 mutant enzyme F508del, microbatch method, using 40% (w/v) PEG 400, 100 mM NH4Cl, and 100 mM MES, pH 6.0 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 F508del the in-frame deletion causes cystic fibrosis Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.6 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens P13569
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.6 Ni-NTA column chromatography and gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 5-methyl-dCTP + H2O + closed Cl- channel
-
 Homo sapiens 5-methyl-dCDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 7-methyl-GTP + H2O + closed Cl- channel
-
 Homo sapiens 7-methyl-GDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 CTP + H2O + closed Cl- channel
-
 Homo sapiens CDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 dATP + H2O + closed Cl- channel
-
 Homo sapiens dADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 dCTP + H2O + closed Cl- channel
-
 Homo sapiens dCDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 dGTP + H2O + closed Cl- channel
-
 Homo sapiens dGDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 dTTP + H2O + closed Cl- channel
-
 Homo sapiens dTDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 dUTP + H2O + closed Cl- channel
-
 Homo sapiens dUDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 GTP + H2O + closed Cl- channel
-
 Homo sapiens GDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 TTP + H2O + closed Cl- channel
-
 Homo sapiens TDP + phosphate + open Cl- channel
-
 ?
5.6.1.6 UTP + H2O + closed Cl- channel
-
 Homo sapiens UDP + phosphate + open Cl- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Homo sapiens
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens