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Literature summary extracted from

  • Akan, I.; Love, D.C.; Harwood, K.R.; Bond, M.R.; Hanover, J.A.
    Drosophila O-GlcNAcase deletion globally perturbs chromatin O-GlcNAcylation (2016), J. Biol. Chem., 291, 9906-9919 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.169 [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O Drosophila melanogaster
-
 [protein]-L-serine + N-acetyl-D-glucosamine
-
 ?
3.2.1.169 [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O Drosophila melanogaster
-
 [protein]-L-threonine + N-acetyl-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.169 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.169 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.169 fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
-
 Drosophila melanogaster fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
-
 ?
3.2.1.169 [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
-
 Drosophila melanogaster [protein]-L-serine + N-acetyl-D-glucosamine
-
 ?
3.2.1.169 [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
-
 Drosophila melanogaster [protein]-L-threonine + N-acetyl-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.169 O-GlcNAcase
-
 Drosophila melanogaster
3.2.1.169 OGA
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.2.1.169 malfunction enzyme loss in Drosophila globally impacts the epigenetic machinery allowing N-acetyl-D-glucosamine accumulation on RNA polymerase II and numerous chromatin factors including TRX, ASH1, and SET1 Drosophila melanogaster