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Literature summary extracted from

  • Kasamatsu, A.; Nakao, M.; Smith, B.C.; Comstock, L.R.; Ono, T.; Kato, J.; Denu, J.M.; Moss, J.
    Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3 (2011), J. Biol. Chem., 286, 21110-21117 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.106 2''-N-acetyl-ADP-D-ribose poor inhibitor Homo sapiens
3.1.1.106 3''-N-acetyl-ADP-D-ribose poor inhibitor Homo sapiens
3.1.1.106 ADP-D-ribose potent inhibitor Homo sapiens
3.1.1.106 additional information not inhibited by D-ribose 5-phosphate, AMP, ADP, or beta-NAD+ Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.106 0.0043
-
 3''-O-acetyl-ADP-D-ribose at pH 7.0 and 30°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.106 Mg2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.106 1''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.106 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.106 1''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 1''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 9.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 7.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 5.0 and 7.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 additional information neither 2''- nor 3''-N-acetyl-ADP-D-ribose is a substrate for the enzyme Homo sapiens ?
-
 ?
3.1.1.106 poly(ADP-D-ribose) + H2O the linkage hydrolyzed by the enzyme in poly(ADP-D-ribose) is stereospecific at the C-1' position with the alpha-anomer present in the polymer Homo sapiens ADP-D-ribose
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.106 ? x * 39000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.106 ADP-ribosylhydrolase 3
-
 Homo sapiens
3.1.1.106 ARH3
-
 Homo sapiens
3.1.1.106 OAADPr hydrolase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.106 9
-
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.106 0.012
-
 at pH 7.0 and 30°C Homo sapiens ADP-D-ribose
3.1.1.106 0.71
-
 at pH 7.0 and 30°C Homo sapiens 2''-N-acetyl-ADP-D-ribose
3.1.1.106 2.3
-
 at pH 7.0 and 30°C Homo sapiens 3''-N-acetyl-ADP-D-ribose