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Literature summary extracted from

  • Yan, X.; Tang, J.; dos Santos Passos, C.; Nurisso, A.; Simoes-Pires, C.A.; Ji, M.; Lou, H.; Fan, P.
    Characterization of lignanamides from hemp (Cannabis sativa L.) seed and their antioxidant and acetylcholinesterase inhibitory activities (2015), J. Agric. Food Chem., 63, 10611-10619 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (2,3-trans)-3-(3-hydroxy-5-methoxyphenyl)-N-(4-hydroxyphenethyl)-7-((E)-3-[(4-hydroxyphenethyl)amino]-3-oxoprop-1-enyl)-2,3-dihydro-benzo[b][1,4]dioxine-2-carboxamide
-
 Tetronarce californica
3.1.1.7 3,3'-demethyl-grossamide 87.37% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 3,3'-demethyl-heliotropamide 62.84% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin A 47.13% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin C 42.89% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin D 13.97% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin E 11.17% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin F 47.16% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin M
-
 Tetronarce californica
3.1.1.7 cannabisin N 51.99% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 cannabisin O
-
 Tetronarce californica
3.1.1.7 galantamine 89.26% inhibition at 0.1 mg/ml, docking study using the enzyme's crystal structure, PBD ID 1DX6 Tetronarce californica
3.1.1.7 grossamide 22.42% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 additional information acetylcholinesterase inhibitory activities of lignanamides from hemp, Cannabis sativa, seeds, NMR compound structure analysis and structure comparisons, molecular modeling studies on AChE, overview Tetronarce californica
3.1.1.7 N-trans-caffeoyltyramine 83.28% inhibition at 0.1 mg/ml Tetronarce californica
3.1.1.7 N-trans-feruloyltyramine 13.25% inhibition at 0.1 mg/ml Tetronarce californica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Tetronarce californica
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Tetronarce californica P04058 i.e. Tetronarce californica
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Tetronarce californica choline + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Tetronarce californica thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Tetronarce californica
3.1.1.7 TcAChE
-
 Tetronarce californica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Tetronarce californica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.8
-
 assay at Tetronarce californica

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00276
-
 pH 7.8, 25°C Tetronarce californica galantamine
3.1.1.7 0.0387
-
 pH 7.8, 25°C Tetronarce californica 3,3'-demethyl-grossamide
3.1.1.7 0.0462
-
 pH 7.8, 25°C Tetronarce californica 3,3'-demethyl-heliotropamide
3.1.1.7 0.216
-
 pH 7.8, 25°C Tetronarce californica N-trans-caffeoyltyramine