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Literature summary extracted from

  • Zhou, Y.; Lin, X.W.; Begum, M.A.; Zhang, C.H.; Shi, X.X.; Jiao, W.J.; Zhang, Y.R.; Yuan, J.Q.; Li, H.Y.; Yang, Q.; Mao, C.; Zhu, Z.R.
    Identification and characterization of Laodelphax striatellus (Insecta Hemiptera Delphacidae) neutral sphingomyelinase (2017), Insect Mol. Biol., 26, 392-402 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 dithiothreitol
-
Laodelphax striatellus
3.1.4.12 EGTA stimulates activity at low concentrations Laodelphax striatellus
3.1.4.12 additional information phospholipids like cardiolipin, phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine do not stimulate enzyme activity Laodelphax striatellus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expressed in High Five insect cells Laodelphax striatellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 EDTA significant inhibition at 5 mM Laodelphax striatellus
3.1.4.12 GW4869
-
Laodelphax striatellus
3.1.4.12 Zn2+ complete inhibition at 0.1 mM Laodelphax striatellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 endoplasmic reticulum
-
Laodelphax striatellus 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ required, high concentrations of up to 50 mM of Mn2+ stimulate enzyme activity Laodelphax striatellus
3.1.4.12 Mn2+ required, low concentrations of Mn2+ stimulate enzyme activity Laodelphax striatellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Laodelphax striatellus
-
ceramide + phosphorylcholine
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Laodelphax striatellus A0A2U6TC85
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 head
-
Laodelphax striatellus
-
3.1.4.12 leg
-
Laodelphax striatellus
-
3.1.4.12 midgut
-
Laodelphax striatellus
-
3.1.4.12 ovary highest expression Laodelphax striatellus
-
3.1.4.12 spermatheca
-
Laodelphax striatellus
-
3.1.4.12 wing
-
Laodelphax striatellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 N-[[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-hexanoyl]-sphingosine-1-phosphocholine + H2O
-
Laodelphax striatellus N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine + phosphorylcholine
-
?
3.1.4.12 sphingomyelin + H2O
-
Laodelphax striatellus ceramide + phosphorylcholine
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase
-
Laodelphax striatellus
3.1.4.12 nSMase
-
Laodelphax striatellus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
at pH 8.0 Laodelphax striatellus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.1.4.12 27 40 the enzyme shows more than 60% activity between 27 and 40°C, and about 40% activity at 45°C Laodelphax striatellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 8
-
-
Laodelphax striatellus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.12 7.5
-
the enzyme shows 50% activity at pH 7.5 and 80% activity at pH 9.0 Laodelphax striatellus