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Literature summary extracted from

  • Nagahama, M.; Takehara, M.; Takagishi, T.; Seike, S.; Miyamoto, K.; Kobayashi, K.
    Cellular uptake of Clostridium botulinum C2 toxin requires acid sphingomyelinase activity (2017), Infect. Immun., 85, e00966-16 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 C2 toxin activates acid but not neutral sphingomyelinase Bacillus cereus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 amitriptyline
-
 Bacillus cereus
3.1.4.12 bromoenol lactone
-
 Bacillus cereus
3.1.4.12 imipramine
-
 Bacillus cereus
3.1.4.12 additional information not inhibited by GW4869 Bacillus cereus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Bacillus cereus
-
 ceramide + phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bacillus cereus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Bacillus cereus ceramide + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Bacillus cereus
3.1.4.12 aSMase
-
 Bacillus cereus

General Information

EC Number General Information Comment Organism
3.1.4.12 malfunction enzyme knockdown reduces Clostridium botulinum C2 toxin-induced cell rounding Bacillus cereus
3.1.4.12 physiological function Clostridium botulinum C2 toxin requires acid sphingomyelinase activity during internalization into cells Bacillus cereus