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Literature summary extracted from

  • Hirata, A.
    Recent insights into the structure, function, and evolution of the RNA-splicing endonucleases (2019), Front. Genet., 10, 103 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.16 Aeropyrum pernix Q9YE85
-
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4.6.1.16 Aeropyrum pernix ATCC 700893 Q9YE85
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4.6.1.16 Archaeoglobus fulgidus O29362
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-
4.6.1.16 Archaeoglobus fulgidus ATCC 49558 O29362
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-
4.6.1.16 Candidatus Micrarchaeum acidiphilum ARMAN-2 C7DIA5
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-
4.6.1.16 Homo sapiens Q8NCE0 AND Q9BSV6 AND Q8WW01 AND Q7Z6J9 Q8NCE0: subunit Sen2, Q9BSV6: subunit Sen34, Q8WW01: subunit Sen15, Q7Z6J9: subunit 54
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4.6.1.16 Methanocaldococcus jannaschii Q58819
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4.6.1.16 Methanocaldococcus jannaschii ATCC 43067 Q58819
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-
4.6.1.16 Methanopyrus kandleri Q8TGZ5
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4.6.1.16 Nanoarchaeum equitans Q74MP4
-
-
4.6.1.16 Pyrobaculum aerophilum Q8ZVI1
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-
4.6.1.16 Pyrobaculum aerophilum ATCC 51768 Q8ZVI1
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4.6.1.16 Saccharomyces cerevisiae P16658 AND P39707 AND Q04675 AND Q02825 P16658: subunit Sen2, P39707: subunit Sen34, Q04675: subunit Sen15, Q02825: subunit 54
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4.6.1.16 Saccharomyces cerevisiae ATCC 204508 P16658 AND P39707 AND Q04675 AND Q02825 P16658: subunit Sen2, P39707: subunit Sen34, Q04675: subunit Sen15, Q02825: subunit 54
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4.6.1.16 Thermoplasma acidophilum Q9HIY5
-
-
4.6.1.16 Thermoplasma acidophilum ATCC 25905 Q9HIY5
-
-

Subunits

EC Number Subunits Comment Organism
4.6.1.16 dimer
-
Thermoplasma acidophilum
4.6.1.16 dimer
-
Archaeoglobus fulgidus
4.6.1.16 oligomer human EndA complex: 53247 (subunit TSen2) + 18641 (subunit TSen15) + 33652 (subunit TSen34) + 58819 (subunit TSen54), calculated from sequence Homo sapiens
4.6.1.16 tetramer
-
Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
4.6.1.16 EndA
-
Thermoplasma acidophilum
4.6.1.16 EndA
-
Aeropyrum pernix
4.6.1.16 EndA
-
Archaeoglobus fulgidus
4.6.1.16 EndA
-
Methanocaldococcus jannaschii
4.6.1.16 EndA
-
Homo sapiens
4.6.1.16 EndA
-
Nanoarchaeum equitans
4.6.1.16 EndA
-
Pyrobaculum aerophilum
4.6.1.16 EndA
-
Methanopyrus kandleri
4.6.1.16 EndA
-
Candidatus Micrarchaeum acidiphilum ARMAN-2
4.6.1.16 EndA
-
Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
4.6.1.16 malfunction mutations in human EndA cause neurological disorders including pontocerebellar hypoplasia and progressive microcephaly Homo sapiens
4.6.1.16 physiological function EndA function is required for brain development in humans. Human EndA complex (TSen2, TSen15, TSen34, and TSen54) cleaves introns from pre-tRNAs, and the TSen2 subunit is involved in pre-mRNA'3 end formation Homo sapiens