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Literature summary extracted from

  • Jimenez-Fernandez, A.; Lopez-Sanchez, A.; Calero, P.; Govantes, F.
    The c-di-GMP phosphodiesterase BifA regulates biofilm development in Pseudomonas putida (2015), Environ. Microbiol. Rep., 7, 78-84 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.52 Pseudomonas putida
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3.1.4.52 Pseudomonas putida KT2442
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Synonyms

EC Number Synonyms Comment Organism
3.1.4.52 BifA
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Pseudomonas putida

General Information

EC Number General Information Comment Organism
3.1.4.52 physiological function a bifA mutant displays increased biofilm and pellicle formation, cell aggregation in liquid medium and decreased starvation-induced biofilm dispersal relative to the wild type. The mutation does not affect swarming motility. The hyperadherent phenotype of the mutant correlates with a general increase in cyclic diguanylate levels, Congo Red-binding exopolysaccharide production and transcription of the adhesin-encoding lapA gene. Integrity of the EAL motif and a modified GGDEF motif are crucial for BifA activity. c-Di-GMP depletion by overexpression of a heterologous cyclic di-GMP phosphodiesterase in the mutant restores wild-type biofilm dispersal and lapA expression Pseudomonas putida