Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhang, F.; Qi, Y.; Zhou, K.; Zhang, G.; Linask, K.; Xu, H.
    The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM (2015), EMBO Rep., 16, 520-527 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 expressed in Escherichia coli Rosetta 2(DE3) cells Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 3-isobutyl-1-methylxanthine
-
 Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.01797
-
 3',5'-cGMP pH and temperature not specified in the publication Drosophila melanogaster
3.1.4.17 0.01942
-
 3',5'-cAMP pH and temperature not specified in the publication Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.17 mitochondrial matrix
-
 Drosophila melanogaster 5759
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17 Ni-NTA column chromatography Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Drosophila melanogaster 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Drosophila melanogaster 5'-GMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 Prune
-
 Drosophila melanogaster

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.4.17 0.00123
-
 3',5'-cGMP pH and temperature not specified in the publication Drosophila melanogaster
3.1.4.17 0.00206
-
 3',5'-cAMP pH and temperature not specified in the publication Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.1.4.17 physiological function the enzyme stabilizes mitochondrial transcription factor A and promotes mitochondrial DNA replication through downregulation of mitochondrial cAMP signaling Drosophila melanogaster