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Literature summary extracted from

  • Klutzny, S.; Lesche, R.; Keck, M.; Kaulfuss, S.; Schlicker, A.; Christian, S.; Sperl, C.; Neuhaus, R.; Mowat, J.; Steckel, M.; Riefke, B.; Prechtl, S.; Parczyk, K.; Steigemann, P.
    Functional inhibition of acid sphingomyelinase by fluphenazine triggers hypoxia-specific tumor cell death (2017), Cell Death Dis., 8, e2709 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 fluphenazine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 ceramide + phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 BODIPY FL C12-sphingomyelin + H2O
-
 Homo sapiens BODIPY FL C12-ceramide + phosphocholine
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens ceramide + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Homo sapiens
3.1.4.12 aSMase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.12 malfunction acid sphingomyelinase inhibition causes cellular sphingomyelin accumulation, which induces cancer cell death specifically in hypoxic tumor spheroids Homo sapiens