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Literature summary extracted from

  • Bai, A.; Kokkotou, E.; Zheng, Y.; Robson, S.C.
    Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses (2015), Cell Death Dis., 6, e1828 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 amitriptyline specific inhibitor Homo sapiens
3.1.4.12 imipramine specific inhibitor Homo sapiens
3.1.4.12 L-carnitine specific inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 helper T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens ceramide + phosphocholine
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
Homo sapiens
3.1.4.12 ASM
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.12 malfunction enzyme inhibition blocks T-helper cell responses. Enzyme knockdown dampens CD3/CD28 signals and broadly inhibits T-helper cell responses Homo sapiens
3.1.4.12 physiological function the enzyme mediates T-cell proliferation after anti-CD3/CD28 antibody stimulation and alters CD4+ T-cell activation signals by generating ceramide Homo sapiens