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Literature summary extracted from

  • Werner, M.M.; Patel, B.A.; Talele, T.T.; Ashby, C.R.; Li, Z.; Zauhar, R.J.
    Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines (2015), Bioorg. Med. Chem., 23, 6125-6137 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 (2R)-2-[(5Z)-5-[[3-(4-fluorophenoxy)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-4-oxo-5-[(3-phenoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-4-oxo-5-[(3-[[(2Z)-3-phenylprop-2-en-1-yl]oxy]phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-([3-[(3,4-dichlorophenyl)methyl]phenyl]methylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[(3',4'-dichloro[1,1'-biphenyl]-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[(3-benzoylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[(3-benzylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[([1,1'-biphenyl]-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[[3-(3,4-dichlorophenoxy)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[[3-(3-chlorophenoxy)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 (2S)-2-[(5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid
-
 Staphylococcus aureus
5.6.2.2 novobiocin
-
 Staphylococcus aureus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 Mg2+ required for activity Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Staphylococcus aureus
-
-
-
5.6.2.2 Staphylococcus aureus P0A0K8 subunit B
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 ATP + relaxed pBR322 DNA
-
 Staphylococcus aureus ADP + phosphate + supercoiled pBR322 DNA
-
 ?
5.6.2.2 ATP + supercoiled pBR322 DNA
-
 Staphylococcus aureus ADP + phosphate + relaxed pBR322 DNA
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.2.2 heterodimer
-
 Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA gyrase
-
 Staphylococcus aureus
5.6.2.2 topoisomerase IV
-
 Staphylococcus aureus
5.6.2.2 topoIV
-
 Staphylococcus aureus
5.6.2.2 type IIA topoisomerase
-
 Staphylococcus aureus