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Literature summary extracted from

  • Pascal, S.; Taton, M.; Rahier, A.
    Oxidative C4-demethylation of 24-methylene cycloartanol by a cyanide-sensitive enzymatic system from higher plant microsomes (1990), Biochem. Biophys. Res. Commun., 172, 98-106 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.10 cyanide 5% residual activity at 0.05 mM Zea mays
1.14.18.10 menadione 39% residual activity at 0.05 mM Zea mays
1.14.18.10 additional information not inhibited by CO (saturated), LAB 170250F, and tetcyclacis Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.18.10 microsome
-
Zea mays
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.10 24-methylidenecycloartanol + NADPH + O2 + H+ Zea mays overall reaction cycloeucalenol + NADP+ + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.10 Zea mays
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.10 24-methylidenecycloartanol + 2 ferrocytochrome b5 + O2 + 2 H+
-
Zea mays 4alpha-(hydroxymethyl)-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferricytochrome B5 + H2O
-
?
1.14.18.10 24-methylidenecycloartanol + NADPH + O2 + H+ overall reaction Zea mays cycloeucalenol + NADP+ + H2O
-
?
1.14.18.10 4alpha-(hydroxymethyl)-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
-
Zea mays 4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + 2 ferricytochrome b5 + H2O
-
?
1.14.18.10 cycloeucalenone + NADPH + O2 + H+
-
Zea mays cycloeucalenol + NADP+ + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.10 4,4-dimethyl 4-demethylase
-
Zea mays

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.10 NADPH required Zea mays

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.10 0.008
-
at pH 7.6 and 30°C Zea mays cyanide