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Literature summary extracted from

  • Whitaker, R.; Faulkner, S.; Miyokawa, R.; Burhenn, L.; Henriksen, M.; Wood, J.G.; Helfand, S.L.
    Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner (2013), Aging, 5, 682-691 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Drosophila melanogaster overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Drosophila melanogaster
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Drosophila melanogaster [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 silent information regulator 2
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 Drosophila melanogaster
2.3.1.286 Sir2
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 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+ dependent on Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.3.1.286 physiological function increased enzyme expression of extends life span in a dose-dependent manner Drosophila melanogaster