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Literature summary extracted from

  • Chakraborty, S.; Gogoi, M.; Chakravortty, D.
    Lactoylglutathione lyase, a critical enzyme in methylglyoxal detoxification, contributes to survival of Salmonella in the nutrient rich environment (2015), Virulence, 6, 50-65 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.5 expression in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.5 0.362
-
 methylglyoxal presence of Zn2+, 37°C, pH 6.6 Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 0.406
-
 methylglyoxal presence of Ni2+, 37°C, pH 6.6 Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 0.588
-
 methylglyoxal presence of Co2+, 37°C, pH 6.6 Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 1.9
-
 methylglyoxal 37°C, pH 6.6 Salmonella enterica subsp. enterica serovar Typhimurium

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.5 membrane bound to outer membrane Salmonella enterica subsp. enterica serovar Typhimurium 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.4.1.5 Co2+ best activator Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 additional information no activation by Zn2+ Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 Ni2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZM36
-
-
4.4.1.5 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 Q8ZM36
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal
-
 Salmonella enterica subsp. enterica serovar Typhimurium (R)-S-lactoylglutathione
-
 ?
4.4.1.5 glutathione + methylglyoxal
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 LGL
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.4.1.5 STM3117
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Expression

EC Number Organism Comment Expression
4.4.1.5 Salmonella enterica subsp. enterica serovar Typhimurium maximum expression at the exponential growth phase additional information

General Information

EC Number General Information Comment Organism
4.4.1.5 physiological function a deletion mutant exhibits a notable growth inhibition coupled with oxidative DNA damage and membrane disruptions. Growth of the mutant in glucose minimal medium does not result in any inhibition. Endogenous expression of recombinant Lgl in serovar Typhi leads to an increased resistance and growth in presence of external methylglyoxal Salmonella enterica subsp. enterica serovar Typhimurium