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Literature summary extracted from

  • Cole, S.; Deeley, R.
    Transport of glutathione and glutathione conjugates by MRP1 (2006), Trends Pharmacol. Sci., 27, 438-446 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.3 glutathione
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.3 MK-571
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.3 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] + leukotriene C4[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2] + leukotriene C4[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Homo sapiens P33527
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 brain
-
 Homo sapiens
-
7.6.2.3 lung
-
 Homo sapiens
-
7.6.2.3 additional information barely detectable in liver Homo sapiens
-
7.6.2.3 additional information the 190-kDa MRP1 is highly over-expressed in many drug-resistant tumour cell lines Homo sapiens
-
7.6.2.3 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + 4-(glutathione-S-yl)-quinoline-1-oxide[side 1]
-
 Homo sapiens ADP + phosphate + 4-(glutathione-S-yl)-quinoline-1-oxide[side 2]
-
 ?
7.6.2.3 ATP + H2O + arsenic triglutathione[side 1]
-
 Homo sapiens ADP + phosphate + arsenic triglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] + leukotriene C4[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2] + leukotriene C4[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione[side 1] + vincristine[side 1]
-
 Homo sapiens ADP + phosphate + glutathione[side 2] + vincristine[side 2]
-
 ?
7.6.2.3 ATP + H2O + GSSG[side 1]
-
 Homo sapiens ADP + phosphate + GSSG[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(15-deoxy-D12,14-prostaglandin J2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(15-deoxy-D12,14-prostaglandin J2)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(4-hydroxynonenal)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(4-hydroxynonenal)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(acetaminophen)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(aflatoxin B1)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(aflatoxin B1)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(atrazinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(atrazinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(chelerythrinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(chelerythrinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(chlorambucil)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(chlorambucil)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(cyclophosphamidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(cyclophosphamidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(daunorubicinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(daunorubicinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(doxorubicinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(doxorubicinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(melphalan)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(melphalan)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methoxychloro)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(methoxychloro)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(metolachloro)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(metolachloro)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(prostaglandin A2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(prostaglandin A2)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(sestamibi)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(sestamibi)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(sulforanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(sulforanyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(tetrofosmin)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(tetrofosmin)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(thiotepa)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(thiotepa)glutathione[side 2]
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.3 ? x * 190000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 ABCC1
-
 Homo sapiens
7.6.2.3 MRP1
-
 Homo sapiens
7.6.2.3 multidrug resistance protein 1
-
 Homo sapiens