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Literature summary extracted from

  • Grode, K.D.; Rogers, S.L.
    The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity (2015), PLoS ONE, 10, e0123912 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.1 overexpression of the catalytic subunit Kat60 in Drosophila S2 cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.1 ATP + H2O + microtubule Drosophila melanogaster
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ADP + phosphate + alpha/beta tubulin heterodimers
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?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.1 Drosophila melanogaster Q9VN89
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.1 ATP + H2O + microtubule
-
Drosophila melanogaster ADP + phosphate + alpha/beta tubulin heterodimers
-
?
5.6.1.1 ATP + H2O + microtubule the microtubule-interacting and trafficking (MIT) domain and adjacent linker region of the Drosophila katanin catalytic subunit Kat60 cooperate to regulate microtubule severing in two distinct ways. First, the MIT domain and linker region of Kat60 decrease its abundance by enhancing its proteasome-dependent degradation. The Drosophila katanin regulatory subunit Kat80, which is required to stabilize Kat60 in cells, conversely reduces the proteasome-dependent degradation of Kat60. Second, the MIT domain and linker region of Kat60 augment its microtubule-disassembly activity by enhancing its association with microtubules Drosophila melanogaster ADP + phosphate + alpha/beta tubulin heterodimers
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?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.1 Kat60
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Drosophila melanogaster
5.6.1.1 katanin
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Drosophila melanogaster

Expression

EC Number Organism Comment Expression
5.6.1.1 Drosophila melanogaster cells induced to express the catalytic subunit Kat60 have reduced levels of alpha-tubulin compared to control cells up

General Information

EC Number General Information Comment Organism
5.6.1.1 malfunction cells overexpressing Kat60 display a disorganized array of fragmented microtubules and the overall length of microtubules appears to decrease with increasing levels of Kat60. Depletion of catalytic subunit Kat60 and regulatory subunit Kat80 causes minimal perturbation of steady-state alpha-tubulin levels in cells Drosophila melanogaster