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Literature summary extracted from

  • Hoehner, R.; Marques, J.V.; Ito, T.; Amakura, Y.; Budgeon, A.D.; Weitz, K.; Hixson, K.K.; Davin, L.B.; Kirchhoff, H.; Lewis, N.G.
    Reduced arogenate dehydratase expression ramifications for photosynthesis and metabolism (2018), Plant Physiol., 177, 115-131 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.91 additional information construction of knockout mutant adt3/4/5/6, as well as ADT knockout mutants adt1, adt3, adt4, adt5, adt4/5, adt1/4/5, and adt3/4/5, phenotypes, detailed overview Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.91 chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.91 L-arogenate Arabidopsis thaliana
-
 L-phenylalanine + H2O + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.91 Arabidopsis thaliana O22241
-
-
4.2.1.91 Arabidopsis thaliana Q9FNJ8
-
-
4.2.1.91 Arabidopsis thaliana Q9SA96
-
-
4.2.1.91 Arabidopsis thaliana Q9SGD6
-
-
4.2.1.91 Arabidopsis thaliana Q9ZUY3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.91 rosette leaf
-
 Arabidopsis thaliana
-
4.2.1.91 seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.91 L-arogenate
-
 Arabidopsis thaliana L-phenylalanine + H2O + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.91 AdT
-
 Arabidopsis thaliana
4.2.1.91 ADT1
-
 Arabidopsis thaliana
4.2.1.91 ADT3
-
 Arabidopsis thaliana
4.2.1.91 ADT4
-
 Arabidopsis thaliana
4.2.1.91 ADT5
-
 Arabidopsis thaliana
4.2.1.91 ADT6
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
4.2.1.91 malfunction ADT-deficient Arabidopsis thaliana mutants have significantly reduced lignin contents, with stronger reductions in lines that have deficiencies in more ADT isoforms, effects of the modulation of ADT on photosynthetic parameters and secondary metabolism, metabolomics, overview. A reduced carbon flux into L-Phe biosynthesis in ADT mutants impairs the consumption of photosynthetically produced ATP, leading to an increased ATP/ADP ratio, overaccumulation of transitory starch, and lower electron transport rates. The effect on electron transport rates is caused by an increase in proton motive force across the thylakoid membrane that downregulates photosystem II activity by the high-energy quenching mechanism. ADT mutants show reduced flavonoid, phenylpropanoid, lignan, and glucosinolate contents, including glucosinolates that are not derived from aromatic amino acids, and significantly increased contents of putative galactolipids and apocarotenoids. Concerning respiration and carbon fixation rates, ADT knockout mutant adt3/4/5/6 does reveal no significant difference in both night- and day-adapted plants. Transitory starch in chloroplasts might serve, at least in part, as an alternative carbon sink in ADT-deficient plants. In the adt3/4/5/6 knockout, the starch content is increased by more than 60%. Phenomics analysis with the adt3/4/5/6 mutant and metabolic analysis of rosette leaves Arabidopsis thaliana
4.2.1.91 malfunction ADT-deficient Arabidopsis thaliana mutants have significantly reduced lignin contents, with stronger reductions in lines that have deficiencies in more ADT isoforms, effects of the modulation of ADT on photosynthetic parameters and secondary metabolism, metabolomics, overview. A reduced carbon flux into Phe biosynthesis in ADT mutants impairs the consumption of photosynthetically produced ATP, leading to an increased ATP/ADP ratio, overaccumulation of transitory starch, and lower electron transport rates. The effect on electron transport rates is caused by an increase in proton motive force across the thylakoid membrane that downregulates photosystem II activity by the high-energy quenching mechanism. ADT mutants show reduced flavonoid, phenylpropanoid, lignan, and glucosinolate contents, including glucosinolates that are not derived from aromatic amino acids, and significantly increased contents of putative galactolipids and apocarotenoids. Concerning respiration and carbon fixation rates, ADT knockout mutant adt3/4/5/6 does reveal no significant difference in both night- and day-adapted plants. Transitory starch in chloroplasts might serve, at least in part, as an alternative carbon sink in ADT-deficient plants. In the adt3/4/5/6 knockout, the starch content is increased by more than 60%. Phenomics analysis with the adt3/4/5/6 mutant and metabolic analysis of rosette leaves Arabidopsis thaliana
4.2.1.91 metabolism arogenate dehydratase (ADT) catalyzes the final step of phenylalanine (Phe) biosynthesis, effects of the modulation of ADT on photosynthetic parameters and secondary metabolism, metabolomics, overview Arabidopsis thaliana