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Literature summary extracted from

  • Miettinen, K.; Dong, L.; Navrot, N.; Schneider, T.; Burlat, V.; Pollier, J.; Woittiez, L.; Van Der Krol, S.; Lugan, R.; Ilc, T.; Verpoorte, R.; Oksman-Caldentey, K.; Martinoia, E.; Bouwmeester, H.; Goossens, A.; Memelink, J.; Werck-Reichhart, D.
    The seco-iridoid pathway from Catharanthus roseus (2014), Nat. Commun., 5, 3606 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.161 expression in in Saccharomyces cerevisiae Catharanthus roseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.161 endoplasmic reticulum assosiated with Catharanthus roseus 5783
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.161 Catharanthus roseus W8JIS5
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.161 epidermis high activity Catharanthus roseus
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1.14.14.161 mesophyll low activity Catharanthus roseus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.161 (+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.161 7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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 ?
1.14.14.161 iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.161 CYP76A26
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 Catharanthus roseus
1.14.14.161 iridoid oxidase misleading Catharanthus roseus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.161 cytochrome P-450 a cytochrome P-450 (heme thiolate) enzyme Catharanthus roseus

General Information

EC Number General Information Comment Organism
1.14.14.161 metabolism the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus