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Literature summary extracted from

  • Custodio, R.; McLean, C.J.; Scott, A.E.; Lowther, J.; Kennedy, A.; Clarke, D.J.; Campopiano, D.J.; Sarkar-Tyson, M.; Brown, A.R.
    Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei (2016), Mol. Microbiol., 102, 1004-1019 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.27 additional information not inhibited by D-erythro-sphingosine Burkholderia pseudomallei
4.1.2.27 additional information not inhibited by D-erythro-sphingosine Burkholderia thailandensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate Burkholderia pseudomallei
-
 phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate Burkholderia thailandensis
-
 phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate Burkholderia pseudomallei K96243
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.27 Burkholderia pseudomallei
-
-
-
4.1.2.27 Burkholderia pseudomallei K96243
-
-
-
4.1.2.27 Burkholderia thailandensis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate
-
 Burkholderia pseudomallei phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate
-
 Burkholderia thailandensis phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate
-
 Burkholderia pseudomallei K96243 phosphoethanolamine + palmitaldehyde
-
 ir

Subunits

EC Number Subunits Comment Organism
4.1.2.27 ? x * 60000, FLAG-tagged enzyme, SDS-PAGE Burkholderia pseudomallei
4.1.2.27 ? x * 60000, FLAG-tagged enzyme, SDS-PAGE Burkholderia thailandensis

Synonyms

EC Number Synonyms Comment Organism
4.1.2.27 S1P lyase
-
 Burkholderia pseudomallei
4.1.2.27 S1P lyase
-
 Burkholderia thailandensis
4.1.2.27 S1PL
-
 Burkholderia pseudomallei
4.1.2.27 S1PL
-
 Burkholderia thailandensis
4.1.2.27 sphingosine-1-phosphate lyase
-
 Burkholderia pseudomallei
4.1.2.27 sphingosine-1-phosphate lyase
-
 Burkholderia thailandensis

General Information

EC Number General Information Comment Organism
4.1.2.27 malfunction enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome) Burkholderia pseudomallei
4.1.2.27 malfunction enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome) Burkholderia thailandensis
4.1.2.27 physiological function the enzyme plays a critical role in virulence and is required for intracellular survival Burkholderia pseudomallei
4.1.2.27 physiological function the enzyme plays a critical role in virulence and is required for intracellular survival Burkholderia thailandensis