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Literature summary extracted from

  • Ballatori, N.; Krance, S.; Marchan, R.; Hammond, C.
    Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology (2009), Mol. Aspects Med., 30, 13-28 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.3 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione disulfide[side 1] Homo sapiens
-
 ADP + phosphate + glutathione disulfide[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-nitrosoglutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-nitrosoglutathione[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Homo sapiens
-
-
-
7.6.2.3 Homo sapiens O95255
-
-
7.6.2.3 Homo sapiens P33527
-
-
7.6.2.3 Homo sapiens Q15439
-
-
7.6.2.3 Homo sapiens Q15440
-
-
7.6.2.3 Homo sapiens Q92887
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 adrenal gland
-
 Homo sapiens
-
7.6.2.3 bladder
-
 Homo sapiens
-
7.6.2.3 brain
-
 Homo sapiens
-
7.6.2.3 breast
-
 Homo sapiens
-
7.6.2.3 colon
-
 Homo sapiens
-
7.6.2.3 gallbladder
-
 Homo sapiens
-
7.6.2.3 heart
-
 Homo sapiens
-
7.6.2.3 kidney
-
 Homo sapiens
-
7.6.2.3 liver
-
 Homo sapiens
-
7.6.2.3 lung
-
 Homo sapiens
-
7.6.2.3 ovary
-
 Homo sapiens
-
7.6.2.3 pancreas
-
 Homo sapiens
-
7.6.2.3 placenta
-
 Homo sapiens
-
7.6.2.3 prostate
-
 Homo sapiens
-
7.6.2.3 skeletal muscle
-
 Homo sapiens
-
7.6.2.3 skin
-
 Homo sapiens
-
7.6.2.3 small intestine
-
 Homo sapiens
-
7.6.2.3 spleen
-
 Homo sapiens
-
7.6.2.3 stomach
-
 Homo sapiens
-
7.6.2.3 sweat gland
-
 Homo sapiens
-
7.6.2.3 testis
-
 Homo sapiens
-
7.6.2.3 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione disulfide[side 1]
-
 Homo sapiens ADP + phosphate + glutathione disulfide[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-nitrosoglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-nitrosoglutathione[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 ABCC1
-
 Homo sapiens
7.6.2.3 ABCC2
-
 Homo sapiens
7.6.2.3 ABCC4
-
 Homo sapiens
7.6.2.3 Abcc5
-
 Homo sapiens
7.6.2.3 Mpr6
-
 Homo sapiens
7.6.2.3 Mpr7
-
 Homo sapiens
7.6.2.3 Mpr8
-
 Homo sapiens
7.6.2.3 MRP1
-
 Homo sapiens
7.6.2.3 MRP2
-
 Homo sapiens
7.6.2.3 MRP4
-
 Homo sapiens
7.6.2.3 MRP5
-
 Homo sapiens
7.6.2.3 multidrug resistance-associated protein
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
7.6.2.3 physiological function the enzyme plays an important role in cellular glutathione homeostasis and is implicated in apoptotic glutathione export. Because the Mrp proteins also mediate export of GSSG and glutathione S-conjugates and complexes, they likely contribute to the control of cellular redox status, delivery of cysteine to other tissues, export of signaling molecules, elimination of xenobiotics and reactive metabolic intermediates, as well as to cell differentiation, proliferation, and apoptosis Homo sapiens