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Literature summary extracted from

  • Alper Tuerkoglu, E.; Sentuerk, M.; Supuran, C.T.; Ekinci, D.
    Carbonic anhydrase inhibitory properties of some uracil derivatives (2017), J. Enzyme Inhib. Med. Chem., 32, 74-77 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 1,3-dimethylpyrimidine-2,4(1H,3H)-dione inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 5,6-diamino-1,3-dimethyluracil inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione inhibition of isozyme hCA I Homo sapiens
4.2.1.1 5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 5-fluorouracil
-
 Homo sapiens
4.2.1.1 6-amino-1,3-dimethyluracil inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 6-amino-5-bromouracil
-
 Homo sapiens
4.2.1.1 6-amino-5-chlorouracil
-
 Homo sapiens
4.2.1.1 6-methylpyrimidine-2,4(1H,3H)-dione inhibition of isozyme hCA I Homo sapiens
4.2.1.1 Benzene
-
 Homo sapiens
4.2.1.1 benzene-1,2-diol inhibition of isozyme hCA I Homo sapiens
4.2.1.1 benzene-1,3-diol inhibition of isozyme hCA I Homo sapiens
4.2.1.1 catechol inhibition of isozyme hCA II Homo sapiens
4.2.1.1 Isoorotic acid inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 additional information some uracil derivatives have carbonic anhydrase inhibitory properties, overview; some uracil derivatives have carbonic anhydrase inhibitory properties, overview Homo sapiens
4.2.1.1 Orotic acid inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 phenol inhibition of isozyme hCA I; inhibition of isozyme hCA II Homo sapiens
4.2.1.1 resorcinol inhibition of isozyme hCA II Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ required, metalloenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens P00915
-
-
4.2.1.1 Homo sapiens P00918
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Homo sapiens CO2 + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 hCA I
-
 Homo sapiens
4.2.1.1 HCA II
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000085
-
 6-amino-1,3-dimethyluracil pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0001035
-
 5,6-diamino-1,3-dimethyluracil pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0001715
-
 6-amino-1,3-dimethyluracil pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.000236
-
 5,6-diamino-1,3-dimethyluracil pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0004585
-
 Isoorotic acid pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0007325
-
 Orotic acid pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0055
-
 phenol pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0077
-
 resorcinol pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0099
-
 catechol pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.0102
-
 phenol pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.01083
-
 5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.02888
-
 5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.04951
-
 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.05776
-
 6-methylpyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.1664
-
 1,3-dimethylpyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.3162
-
 1,3-dimethylpyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.428
-
 5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.645
-
 5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 0.795
-
 benzene-1,3-diol pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 1.432
-
 Isoorotic acid pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 1.682
-
 Orotic acid pH 7.4, temperature not specified in the publication Homo sapiens
4.2.1.1 4.003
-
 benzene-1,2-diol pH 7.4, temperature not specified in the publication Homo sapiens