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Literature summary extracted from

  • Li, Z.Z.; Riegert, A.S.; Goneau, M.F.; Cunningham, A.M.; Vinogradov, E.; Li, J.; Schoenhofen, I.C.; Thoden, J.B.; Holden, H.M.; Gilbert, M.
    Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116 (2017), Glycobiology, 27, 358-369 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.B19 expressed in Escherichia coli Campylobacter jejuni
2.7.7.24 expressed in Escherichia coli Campylobacter jejuni
4.2.1.46 expressed in Escherichia coli Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.24 dTTP + alpha-D-glucose 1-phosphate Campylobacter jejuni the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose diphosphate + dTDP-alpha-D-glucose
-
 ?
4.2.1.46 dTDP-alpha-D-glucose Campylobacter jejuni the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.B19 Campylobacter jejuni Q9ALS9
-
-
2.7.7.24 Campylobacter jejuni Q5EPE6
-
-
4.2.1.46 Campylobacter jejuni Q6EB26
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.B19
-
 Campylobacter jejuni
2.7.7.24
-
 Campylobacter jejuni
4.2.1.46
-
 Campylobacter jejuni

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.B19 dTDP-3-amino-3,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-galactose + D-glutamate (2) Campylobacter jejuni
a
2.6.1.B19 dTDP-3-amino-3,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-D-glucose + D-glutamate (1) Campylobacter jejuni
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.B19 dTDP-3-dehydro-6-deoxy-D-glucose + D-glutamate the enzyme has the ability to function on substrates that differ in their stereochemistry about the C-4' carbon of the pyranose ring: dTDP-3-dehydro-6-deoxy-D-glucose and dTDP-3-dehydro-6-deoxy-galactose Campylobacter jejuni dTDP-3-amino-3,6-dideoxy-D-glucose + 2-oxoglutarate
-
 ?
2.6.1.B19 dTDP-3-dehydro-6-deoxy-galactose + D-glutamate the enzyme has the ability to function on substrates that differ in their stereochemistry about the C-4' carbon of the pyranose ring: dTDP-3-dehydro-6-deoxy-D-glucose and dTDP-3-dehydro-6-deoxy-galactose Campylobacter jejuni dTDP-3-amino-3,6-dideoxy-D-galactose + 2-oxoglutarate
-
 ?
2.7.7.24 dTTP + alpha-D-glucose 1-phosphate
-
 Campylobacter jejuni diphosphate + dTDP-alpha-D-glucose
-
 ?
2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni diphosphate + dTDP-alpha-D-glucose
-
 ?
4.2.1.46 dTDP-alpha-D-glucose
-
 Campylobacter jejuni dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
-
 ?
4.2.1.46 dTDP-alpha-D-glucose the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.B19 WlaRG
-
 Campylobacter jejuni
2.7.7.24 RmlA
-
 Campylobacter jejuni
4.2.1.46 RmlB
-
 Campylobacter jejuni
4.2.1.46 thymidine diphosphate-glucose 4,6-dehydratase
-
 Campylobacter jejuni

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.B19 37
-
 assay at Campylobacter jejuni
2.7.7.24 37
-
 assay at Campylobacter jejuni
4.2.1.46 37
-
 assay at Campylobacter jejuni

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.B19 7.5
-
 assay at Campylobacter jejuni
2.7.7.24 7.5
-
 assay at Campylobacter jejuni
4.2.1.46 7.5
-
 assay at Campylobacter jejuni

General Information

EC Number General Information Comment Organism
2.6.1.B19 metabolism the enzyme is involved in the biosynthesis of dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni
2.7.7.24 metabolism the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni
4.2.1.46 metabolism the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni