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Literature summary extracted from

  • Park, J.; Tefsen, B.; Arentshorst, M.; Lagendijk, E.; van den Hondel, C.A.; van Die, I.; Ram, A.F.
    Identification of the UDP-glucose-4-epimerase required for galactofuranose biosynthesis and galactose metabolism in A. niger (2014), Fungal Biol. Biotechnol., 1, 6 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
5.1.3.2 additional information targeted deletion of ugeA resulting in a severe reduction of galactofuranose in N-linked glucans Aspergillus niger
5.1.3.2 N191D naturally occuring mutation, the UgeA mutant shows reduced galactofuranose production, the mutant enzyme is partially active Aspergillus niger

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.1.3.2 cell wall
-
 Aspergillus niger 5618
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.2 UDP-glucose Aspergillus niger
-
 UDP-galactose
-
 r
5.1.3.2 UDP-glucose Aspergillus niger CBS 513.88 / FGSC A1513
-
 UDP-galactose
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.2 Aspergillus niger A2R3C7
-
-
5.1.3.2 Aspergillus niger CBS 513.88 / FGSC A1513 A2R3C7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.2 UDP-glucose
-
 Aspergillus niger UDP-galactose
-
 r
5.1.3.2 UDP-glucose
-
 Aspergillus niger CBS 513.88 / FGSC A1513 UDP-galactose
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.3.2 An14g03820
-
 Aspergillus niger
5.1.3.2 UDP-glucose-4-epimerase
-
 Aspergillus niger
5.1.3.2 UgeA
-
 Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
5.1.3.2 NAD+
-
 Aspergillus niger

General Information

EC Number General Information Comment Organism
5.1.3.2 evolution presence of three putative UDP glucose-4-epimerases, UgeA, UgeB, and UgeC, in Aspergillus niger, encoded by genes An14g03820, An12g10410, and An02g11320. Enzyme UgeA belongs to the NAD(P)-dependent epimerase/dehydratase family Aspergillus niger
5.1.3.2 malfunction mutation of enzyme UgeA results in reduced galactofuranose production, deletion of gene ugeA abolishes the galactofuranose production Aspergillus niger
5.1.3.2 physiological function enzyme UgeA is required for the biosynthesis of galactofuranose as well as for galactose metabolism in Aspergillus niger. UgeA is required for growth on galactose in Aspergillus niger Aspergillus niger