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Literature summary extracted from

  • Schiroli, D.; Ronda, L.; Peracchi, A.
    Kinetic characterization of the human O-phosphoethanolamine phospho-lyase reveals unconventional features of this specialized pyridoxal phosphate-dependent lyase (2015), FEBS J., 282, 183-199 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.2 3-Aminopropylphosphonate
-
Homo sapiens
4.2.3.2 ethylsulfonate
-
Homo sapiens
4.2.3.2 methylsulfonate
-
Homo sapiens
4.2.3.2 phosphate competitive inhibitor at pH values between 6.0 and 8.0 Homo sapiens
4.2.3.2 sulfate competitive inhibitor at pH values between 6.0 and 8.0 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.2 1
-
Ethanolamine phosphate at pH 7.4 and 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.2 ethanolamine phosphate + H2O Homo sapiens
-
acetaldehyde + NH3 + phosphate
-
ir

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.2 brain
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.2 ethanolamine phosphate + H2O
-
Homo sapiens acetaldehyde + NH3 + phosphate
-
ir

Synonyms

EC Number Synonyms Comment Organism
4.2.3.2 AGXT2L1
-
Homo sapiens
4.2.3.2 ETNPPL
-
Homo sapiens
4.2.3.2 O-phosphoethanolamine phospho-lyase
-
Homo sapiens
4.2.3.2 PEA phospho-lyase
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.3.2 0.9
-
Ethanolamine phosphate at pH 6.0 and 30°C Homo sapiens
4.2.3.2 1.2
-
Ethanolamine phosphate at pH 7.4 and 30°C Homo sapiens
4.2.3.2 2.3
-
Ethanolamine phosphate at pH 8.0 and 30°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.3.2 pyridoxal 5'-phosphate
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.3.2 1.5
-
sulfate at pH 6.0 and 30°C Homo sapiens
4.2.3.2 1.5
-
phosphate at pH 8.0 and 30°C Homo sapiens
4.2.3.2 1.5
-
sulfate at pH 8.0 and 30°C Homo sapiens
4.2.3.2 8
-
phosphate at pH 6.0 and 30°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.3.2 1.1
-
Ethanolamine phosphate at pH 7.4 and 30°C Homo sapiens