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Literature summary extracted from

  • Arana, M.R.; Altenberg, G.
    ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1 (2017), Curr. Med. Chem., 25, 1-17 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 plasma membrane
-
 Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens Q2M3G0
-
-
7.6.2.2 Homo sapiens Q8HXQ5
-
-
7.6.2.2 Homo sapiens Q9UNQ0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 enterocyte BCRP Homo sapiens
-
7.6.2.2 hepatocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + acridine orange[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + acridine orange[side 2]
-
 ?
7.6.2.2 ATP + H2O + aflatoxin B[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + aflatoxin B[side 2]
-
 ?
7.6.2.2 ATP + H2O + amiodarone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + amiodarone[side 2]
-
 ?
7.6.2.2 ATP + H2O + arsenite[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + arsenite[side 2]
-
 ?
7.6.2.2 ATP + H2O + azidopine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + azidopine[side 2]
-
 ?
7.6.2.2 ATP + H2O + bilirubin[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + bilirubin[side 2]
-
 ?
7.6.2.2 ATP + H2O + calcein[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + calcein[side 2]
-
 ?
7.6.2.2 ATP + H2O + calphostin C[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + calphostin C[side 2]
-
 ?
7.6.2.2 ATP + H2O + clorambucil[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + clorambucil[side 2]
-
 ?
7.6.2.2 ATP + H2O + colchicine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + colchicine[side 2]
-
 ?
7.6.2.2 ATP + H2O + cyclophosphamide[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + cyclophosphamide[side 2]
-
 ?
7.6.2.2 ATP + H2O + cyclosporine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + cyclosporine[side 2]
-
 ?
7.6.2.2 ATP + H2O + daunorubicin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + daunorubicin[side 2]
-
 ?
7.6.2.2 ATP + H2O + daunorubicin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + daunorubicin[side 2]
-
 ?
7.6.2.2 ATP + H2O + dehydroepiandrosterone sulfate[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + dehydroepiandrosterone sulfate[side 2]
-
 ?
7.6.2.2 ATP + H2O + dinitrophenyl[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + dinitrophenyl[side 2]
-
 ?
7.6.2.2 ATP + H2O + dipyridamole[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + dipyridamole[side 2]
-
 ?
7.6.2.2 ATP + H2O + doxorubicin[side 1] substrate for P-glycoprotein, BCRP, and MRP1 Homo sapiens ADP + phosphate + doxorubicin[side 2]
-
 ?
7.6.2.2 ATP + H2O + erythromycin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + erythromycin[side 2]
-
 ?
7.6.2.2 ATP + H2O + estradiol[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + estradiol[side 2]
-
 ?
7.6.2.2 ATP + H2O + estrone-3-sulfate[side 1] substrate for BCRP Homo sapiens ADP + phosphate + estrone-3-sulfate[side 2]
-
 ?
7.6.2.2 ATP + H2O + estrone[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + estrone[side 2]
-
 ?
7.6.2.2 ATP + H2O + ethacrynic acid[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + ethacrynic acid[side 2]
-
 ?
7.6.2.2 ATP + H2O + etoposide[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + etoposide[side 2]
-
 ?
7.6.2.2 ATP + H2O + FK-506[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + FK-506[side 2]
-
 ?
7.6.2.2 ATP + H2O + folic acid[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + folic acid[side 2]
-
 ?
7.6.2.2 ATP + H2O + gefitinib[side 1] substrate for BCRP Homo sapiens ADP + phosphate + gefitinib[side 2]
-
 ?
7.6.2.2 ATP + H2O + genistein[side 1] substrate for BCRP Homo sapiens ADP + phosphate + genistein[side 2]
-
 ?
7.6.2.2 ATP + H2O + genistein[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + genistein[side 2]
-
 ?
7.6.2.2 ATP + H2O + glutathione disulfide[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + glutathione disulfide[side 2]
-
 ?
7.6.2.2 ATP + H2O + hematoporphyrin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + hematoporphyrin[side 2]
-
 ?
7.6.2.2 ATP + H2O + indinavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + indinavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + leucovorin[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + leucovorin[side 2]
-
 ?
7.6.2.2 ATP + H2O + leukotriene C4[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + leukotriene C4[side 2]
-
 ?
7.6.2.2 ATP + H2O + leukotriene D4[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + leukotriene D4[side 2]
-
 ?
7.6.2.2 ATP + H2O + melphalan[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + melphalan[side 2]
-
 ?
7.6.2.2 ATP + H2O + methotrexate[side 1] substrate for BCRP Homo sapiens ADP + phosphate + methotrexate[side 2]
-
 ?
7.6.2.2 ATP + H2O + mitomycin C[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + mitomycin C[side 2]
-
 ?
7.6.2.2 ATP + H2O + mitoxantrone[side 1] substrate for BCRP Homo sapiens ADP + phosphate + mitoxantrone[side 2]
-
 ?
7.6.2.2 ATP + H2O + progesterone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + progesterone[side 2]
-
 ?
7.6.2.2 ATP + H2O + prostaglandin E2[side 1] substrate for MRP1 Homo sapiens ADP + phosphate + prostaglandin E2[side 2]
-
 ?
7.6.2.2 ATP + H2O + PSC-833[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + PSC-833[side 2]
-
 ?
7.6.2.2 ATP + H2O + quercetin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + quercetin[side 2]
-
 ?
7.6.2.2 ATP + H2O + quinidine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + quinidine[side 2]
-
 ?
7.6.2.2 ATP + H2O + rapamycin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + rapamycin[side 2]
-
 ?
7.6.2.2 ATP + H2O + rhodamine 123[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + rhodamine 123[side 2]
-
 ?
7.6.2.2 ATP + H2O + riboflavin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + riboflavin[side 2]
-
 ?
7.6.2.2 ATP + H2O + ritonavir[side 1] substrate for P-glycoprotein and MRP1 Homo sapiens ADP + phosphate + ritonavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + staurosporine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + staurosporine[side 2]
-
 ?
7.6.2.2 ATP + H2O + tamoxifen[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + tamoxifen[side 2]
-
 ?
7.6.2.2 ATP + H2O + taxol[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + taxol[side 2]
-
 ?
7.6.2.2 ATP + H2O + teniposide[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + teniposide[side 2]
-
 ?
7.6.2.2 ATP + H2O + verapamil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + verapamil[side 2]
-
 ?
7.6.2.2 ATP + H2O + vinblastine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + vinblastine[side 2]
-
 ?
7.6.2.2 ATP + H2O + vincristine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + vincristine[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCG2
-
 Homo sapiens
7.6.2.2 BCRP
-
 Homo sapiens
7.6.2.2 breast cancer resistance protein
-
 Homo sapiens
7.6.2.2 canalicular multispecific organic anion transporter
-
 Homo sapiens
7.6.2.2 cMOAT
-
 Homo sapiens
7.6.2.2 MRP1
-
 Homo sapiens
7.6.2.2 multidrugresistance 1
-
 Homo sapiens
7.6.2.2 P-glycoprotein
-
 Homo sapiens
7.6.2.2 Pgp
-
 Homo sapiens