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Literature summary extracted from

  • Guardia, A.; Gulten, G.; Fernandez, R.; Gomez, J.; Wang, F.; Convery, M.; Blanco, D.; Martinez, M.; Perez-Herran, E.; Alonso, M.; Ortega, F.; Rullas, J.; Calvo, D.; Mata, L.; Young, R.; Sacchettini, J.; Mendoza-Losana, A.; Remuinan, M.
    N-Benzyl-4-((heteroaryl)methyl)benzamides a new class of direct NADH-dependent 2-trans enoyl-acyl carrier protein reductase (InhA) inhibitors with antitubercular activity (2016), ChemMedChem, 11, 687-701 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 expression in Escherichia coli (BL21) Mycobacterium tuberculosis
1.3.1.118 expression in Escherichia coli (BL21) Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(4-fluoro-2-(trifluoromethyl)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.9 N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(4-fluoro-2-(trifluoromethyl)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide
-
 Mycobacterium tuberculosis
1.3.1.118 N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.9 Mycobacterium tuberculosis ATCC 25618 P9WGR1
-
-
1.3.1.118 Mycobacterium tuberculosis P9WGR1 cf. EC 1.3.1.9
-
1.3.1.118 Mycobacterium tuberculosis ATCC 25618 P9WGR1 cf. EC 1.3.1.9
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9
-
 Mycobacterium tuberculosis
1.3.1.118
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis dodecanoyl-CoA + NAD+
-
 ?
1.3.1.9 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis ATCC 25618 dodecanoyl-CoA + NAD+
-
 ?
1.3.1.118 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis dodecanoyl-CoA + NAD+
-
 ?
1.3.1.118 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis ATCC 25618 dodecanoyl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 InhA
-
 Mycobacterium tuberculosis
1.3.1.118 InhA
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.9 25
-
 assay at Mycobacterium tuberculosis
1.3.1.118 25
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.9 6.8
-
 assay at Mycobacterium tuberculosis
1.3.1.118 6.8
-
 assay at Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Mycobacterium tuberculosis
1.3.1.118 NADH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.00004
-
 pH 6.8, 25°C Mycobacterium tuberculosis 2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide
1.3.1.9 0.00005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide
1.3.1.9 0.00006
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide
1.3.1.9 0.00006
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide
1.3.1.9 0.00008
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.9 0.00012
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide
1.3.1.9 0.00025
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide
1.3.1.9 0.00025
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.9 0.00032
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide
1.3.1.9 0.00035
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.0005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.0005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide
1.3.1.9 0.00054
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
1.3.1.9 0.001
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide
1.3.1.9 0.00126
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.0014
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide
1.3.1.9 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00251
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00251
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide
1.3.1.9 0.0031
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.9 0.00325
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.9 0.0034
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide
1.3.1.9 0.00593
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00004
-
 pH 6.8, 25°C Mycobacterium tuberculosis 2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide
1.3.1.118 0.00005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide
1.3.1.118 0.00006
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide
1.3.1.118 0.00006
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide
1.3.1.118 0.00008
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00009
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.118 0.00012
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide
1.3.1.118 0.00025
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(4-fluoro-2-(trifluoromethyl)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00025
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.118 0.00032
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide
1.3.1.118 0.00035
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.0005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.0005
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide
1.3.1.118 0.00054
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
1.3.1.118 0.001
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide
1.3.1.118 0.00126
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.0014
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide
1.3.1.118 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00158
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00251
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00251
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide
1.3.1.118 0.0031
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide
1.3.1.118 0.00325
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide
1.3.1.118 0.0034
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide
1.3.1.118 0.00593
-
 pH 6.8, 25°C Mycobacterium tuberculosis N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide