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Literature summary extracted from

  • Kuehnel, L.C.; Nestl, B.M.; Hauer, B.
    Enzymatic addition of alcohols to terpenes by squalene hopene cyclase variants (2017), ChemBioChem, 18, 2222-2225 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.17 expressed in Escherichia coli BL21(DE3) cells Alicyclobacillus acidocaldarius subsp. acidocaldarius

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.17 squalene Alicyclobacillus acidocaldarius subsp. acidocaldarius
-
 hop-22(29)-ene
-
 ?
5.4.99.17 squalene + H2O Alicyclobacillus acidocaldarius subsp. acidocaldarius
-
 hopan-22-ol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.17 Alicyclobacillus acidocaldarius subsp. acidocaldarius P33247
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.17 (2E,6E)-farnesol + geraniol drimane-8,11-diol is the major product of the wild-type enzyme Alicyclobacillus acidocaldarius subsp. acidocaldarius drimane-8,11-diol + [(1R,2S)-2-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-2,6,6-trimethylcyclohexyl]methanol + 8-O-geranyl-drimane-8,11-diol + drimenol + albicanol
-
 ?
5.4.99.17 (2E,6E)-farnesol + H2O drimane-8,11-diol is the major product of the wild-type enzyme Alicyclobacillus acidocaldarius subsp. acidocaldarius 8-O-((2E,6E)-farnesyl)-drimane-8,11-diol + drimane-8,11-diol + drimenol + albicanol
-
 ?
5.4.99.17 (2E,6E)-farnesol + n-butanol drimane-8,11-diol is the major product of the wild-type enzyme Alicyclobacillus acidocaldarius subsp. acidocaldarius drimane-8,11-diol + drimenol + albicanol + 8-O-((2E,6E)-farnesyl)-drimane-8,11-diol + drimane-8,11-diol + farnesyl pentyl ether
-
 ?
5.4.99.17 squalene
-
 Alicyclobacillus acidocaldarius subsp. acidocaldarius hop-22(29)-ene
-
 ?
5.4.99.17 squalene + H2O
-
 Alicyclobacillus acidocaldarius subsp. acidocaldarius hopan-22-ol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.17 SHC
-
 Alicyclobacillus acidocaldarius subsp. acidocaldarius
5.4.99.17 squalene hopene cyclase
-
 Alicyclobacillus acidocaldarius subsp. acidocaldarius