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Literature summary extracted from

  • Pergolizzi, G.; Wagner, G.K.; Bowater, R.P.
    Biochemical and structural characterisation of DNA ligases from bacteria and archaea (2016), Biosci. Rep., 36, e00391 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Escherichia coli
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Haemophilus influenzae
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Mycobacterium tuberculosis
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Mycoplasma pneumoniae
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Staphylococcus aureus
6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
 Streptococcus pneumoniae
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Escherichia coli
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Mycobacterium tuberculosis
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Mycoplasma pneumoniae
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Staphylococcus aureus
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Streptococcus pneumoniae
6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
 Haemophilus influenzae
6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine
-
 Escherichia coli
6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(butylsulfanyl)adenosine
-
 Escherichia coli
6.5.1.2 2-(butylsulfanyl)adenosine
-
 Haemophilus influenzae
6.5.1.2 2-(butylsulfanyl)adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(butylsulfanyl)adenosine
-
 Staphylococcus aureus
6.5.1.2 2-(butylsulfanyl)adenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Escherichia coli
6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)adenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)adenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentyloxy)adenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)adenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentylsulfanyl)adenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentylsulfanyl)adenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentylsulfanyl)adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-(cyclopentylsulfanyl)adenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentylsulfanyl)adenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
 Escherichia coli
6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
 Escherichia coli
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
 Escherichia coli
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
 Escherichia coli
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
 Escherichia coli
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Escherichia coli
6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Escherichia coli
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Haemophilus influenzae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Mycobacterium tuberculosis
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Mycoplasma pneumoniae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Staphylococcus aureus
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Streptococcus pneumoniae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Escherichia coli
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Haemophilus influenzae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Mycobacterium tuberculosis
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Mycoplasma pneumoniae
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Staphylococcus aureus
6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-2-phenoxyadenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-2-phenoxyadenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-2-phenoxyadenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-2-phenoxyadenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-2-phenoxyadenosine
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
 Streptococcus pneumoniae
6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Escherichia coli
6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Haemophilus influenzae
6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Mycoplasma pneumoniae
6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Staphylococcus aureus
6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
 Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Staphylococcus aureus
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Streptococcus pneumoniae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycoplasma pneumoniae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Escherichia coli
-
-
-
6.5.1.2 Haemophilus influenzae
-
-
-
6.5.1.2 Mycobacterium tuberculosis
-
-
-
6.5.1.2 Mycoplasma pneumoniae
-
-
-
6.5.1.2 Staphylococcus aureus
-
-
-
6.5.1.2 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Staphylococcus aureus (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Haemophilus influenzae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Streptococcus pneumoniae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycoplasma pneumoniae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 beta-NAD+ -dependent DNA ligase
-
 Staphylococcus aureus
6.5.1.2 beta-NAD+ -dependent DNA ligase
-
 Haemophilus influenzae
6.5.1.2 beta-NAD+ -dependent DNA ligase
-
 Escherichia coli
6.5.1.2 beta-NAD+ -dependent DNA ligase
-
 Streptococcus pneumoniae
6.5.1.2 beta-NAD+ -dependent DNA ligase
-
 Mycobacterium tuberculosis
6.5.1.2 beta-NAD+-dependent DNA ligase
-
 Mycoplasma pneumoniae
6.5.1.2 LigA
-
 Staphylococcus aureus
6.5.1.2 LigA
-
 Haemophilus influenzae
6.5.1.2 LigA
-
 Escherichia coli
6.5.1.2 LigA
-
 Streptococcus pneumoniae
6.5.1.2 LigA
-
 Mycobacterium tuberculosis
6.5.1.2 LigA
-
 Mycoplasma pneumoniae
6.5.1.2 NAD+-dependent DNA ligase
-
 Staphylococcus aureus
6.5.1.2 NAD+-dependent DNA ligase
-
 Haemophilus influenzae
6.5.1.2 NAD+-dependent DNA ligase
-
 Escherichia coli
6.5.1.2 NAD+-dependent DNA ligase
-
 Streptococcus pneumoniae
6.5.1.2 NAD+-dependent DNA ligase
-
 Mycobacterium tuberculosis
6.5.1.2 NAD+-dependent DNA ligase
-
 Mycoplasma pneumoniae
6.5.1.2 NDL
-
 Staphylococcus aureus
6.5.1.2 NDL
-
 Haemophilus influenzae
6.5.1.2 NDL
-
 Escherichia coli
6.5.1.2 NDL
-
 Streptococcus pneumoniae
6.5.1.2 NDL
-
 Mycobacterium tuberculosis
6.5.1.2 NDL
-
 Mycoplasma pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.2 NAD+
-
 Staphylococcus aureus
6.5.1.2 NAD+
-
 Haemophilus influenzae
6.5.1.2 NAD+
-
 Escherichia coli
6.5.1.2 NAD+
-
 Streptococcus pneumoniae
6.5.1.2 NAD+
-
 Mycobacterium tuberculosis
6.5.1.2 NAD+
-
 Mycoplasma pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.5.1.2 0.00001
-
 pH and temperature not specified in the publication Mycoplasma pneumoniae 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
6.5.1.2 0.00001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
6.5.1.2 0.00002
-
 pH and temperature not specified in the publication Mycoplasma pneumoniae 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00002
-
 pH and temperature not specified in the publication Mycoplasma pneumoniae 2-(cyclopentyloxy)-5'-deoxyadenosine
6.5.1.2 0.00002
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00003
-
 pH and temperature not specified in the publication Staphylococcus aureus 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
6.5.1.2 0.00004
-
 pH and temperature not specified in the publication Staphylococcus aureus 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
6.5.1.2 0.00004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
6.5.1.2 0.00004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00005
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00005
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
6.5.1.2 0.00006
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
6.5.1.2 0.00006
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00006
-
 pH and temperature not specified in the publication Mycoplasma pneumoniae 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00007
-
 pH and temperature not specified in the publication Mycoplasma pneumoniae 2-(butylsulfanyl)adenosine
6.5.1.2 0.00007
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(butylsulfanyl)adenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-5'-deoxyadenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-[(decahydronaphthalen-2-yl)oxy]adenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
6.5.1.2 0.00008
-
 pH and temperature not specified in the publication Haemophilus influenzae 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.00009
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
6.5.1.2 0.00011
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-(cyclopentyloxy)-5'-deoxyadenosine
6.5.1.2 0.00011
-
 pH and temperature not specified in the publication Haemophilus influenzae 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
6.5.1.2 0.00011
-
 pH and temperature not specified in the publication Staphylococcus aureus 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
6.5.1.2 0.00012
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-5'-deoxyadenosine
6.5.1.2 0.00012
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00012
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00013
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(butylsulfanyl)-5'-deoxyadenosine
6.5.1.2 0.00013
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
6.5.1.2 0.00013
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
6.5.1.2 0.00014
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(butylsulfanyl)adenosine
6.5.1.2 0.00014
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-phenoxyadenosine
6.5.1.2 0.00015
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentyloxy)adenosine
6.5.1.2 0.00016
-
 pH and temperature not specified in the publication Escherichia coli 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
6.5.1.2 0.00016
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
6.5.1.2 0.00017
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(butylsulfanyl)-5'-deoxyadenosine
6.5.1.2 0.00018
-
 pH and temperature not specified in the publication Escherichia coli 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
6.5.1.2 0.0002
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
6.5.1.2 0.00026
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
6.5.1.2 0.00032
-
 pH and temperature not specified in the publication Escherichia coli 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
6.5.1.2 0.00037
-
 pH and temperature not specified in the publication Escherichia coli 2-(cyclopentyloxy)-5'-deoxyadenosine
6.5.1.2 0.00037
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
6.5.1.2 0.00038
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentylsulfanyl)adenosine
6.5.1.2 0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
6.5.1.2 0.0004
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-[(decahydronaphthalen-2-yl)oxy]adenosine
6.5.1.2 0.00043
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(cyclopentyloxy)adenosine
6.5.1.2 0.00044
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(cyclopentylsulfanyl)adenosine
6.5.1.2 0.00051
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-(butylsulfanyl)adenosine
6.5.1.2 0.00051
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-(cyclopentyloxy)adenosine
6.5.1.2 0.00087
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
6.5.1.2 0.00091
-
 pH and temperature not specified in the publication Staphylococcus aureus 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
6.5.1.2 0.00127
-
 pH and temperature not specified in the publication Escherichia coli 2-(butylsulfanyl)adenosine
6.5.1.2 0.0015
-
 pH and temperature not specified in the publication Escherichia coli (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
6.5.1.2 0.0017
-
 pH and temperature not specified in the publication Haemophilus influenzae 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
6.5.1.2 0.00267
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-deoxy-2-phenoxyadenosine
6.5.1.2 0.016
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
6.5.1.2 0.073
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
6.5.1.2 0.12
-
 pH and temperature not specified in the publication Escherichia coli (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
6.5.1.2 0.138
-
 pH and temperature not specified in the publication Escherichia coli 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
6.5.1.2 0.2
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium