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Literature summary extracted from

  • Murphy-Benenato, K.E.; Gingipalli, L.; Boriack-Sjodin, P.A.; Martinez-Botella, G.; Carcanague, D.; Eyermann, C.J.; Gowravaram, M.; Harang, J.; Hale, M.R.; Ioannidis, G.; Jahic, H.; Johnstone, M.; Kutschke, A.; Laganas, V.A.; Loch, J.T.; Miller, M.D.; Oguto, H.; Patel, S.J.
    Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development (2015), Bioorg. Med. Chem. Lett., 25, 5172-5177 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
 Escherichia coli
6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Escherichia coli
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Haemophilus influenzae
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Staphylococcus aureus
6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
 Streptococcus pneumoniae
6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
 Escherichia coli
6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
 Haemophilus influenzae
6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
 Staphylococcus aureus
6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Escherichia coli
6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Haemophilus influenzae
6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Staphylococcus aureus
6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
 Streptococcus pneumoniae
6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
 Escherichia coli
6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
 Haemophilus influenzae
6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
 Staphylococcus aureus
6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
 Streptococcus pneumoniae
6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
 Escherichia coli
6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
 Haemophilus influenzae
6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
 Staphylococcus aureus
6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
 Escherichia coli
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
 Haemophilus influenzae
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
 Staphylococcus aureus
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
 Streptococcus pneumoniae
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
 Escherichia coli
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
 Haemophilus influenzae
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
 Staphylococcus aureus
6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
 Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Staphylococcus aureus
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Streptococcus pneumoniae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae ARM158
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli ARC524
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Streptococcus pneumoniae ARC548
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Staphylococcus aureus ARC561
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Escherichia coli
-
-
-
6.5.1.2 Escherichia coli ARC524
-
-
-
6.5.1.2 Haemophilus influenzae
-
-
-
6.5.1.2 Haemophilus influenzae ARM158
-
-
-
6.5.1.2 Staphylococcus aureus
-
-
-
6.5.1.2 Staphylococcus aureus ARC561
-
-
-
6.5.1.2 Streptococcus pneumoniae
-
-
-
6.5.1.2 Streptococcus pneumoniae ARC548
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Staphylococcus aureus (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Haemophilus influenzae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Streptococcus pneumoniae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Haemophilus influenzae ARM158 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Escherichia coli ARC524 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Streptococcus pneumoniae ARC548 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Staphylococcus aureus ARC561 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 LigA
-
 Staphylococcus aureus
6.5.1.2 LigA
-
 Haemophilus influenzae
6.5.1.2 LigA
-
 Escherichia coli
6.5.1.2 LigA
-
 Streptococcus pneumoniae
6.5.1.2 NAD+-dependent DNA ligase
-
 Staphylococcus aureus
6.5.1.2 NAD+-dependent DNA ligase
-
 Haemophilus influenzae
6.5.1.2 NAD+-dependent DNA ligase
-
 Escherichia coli
6.5.1.2 NAD+-dependent DNA ligase
-
 Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.2 NAD+
-
 Staphylococcus aureus
6.5.1.2 NAD+
-
 Haemophilus influenzae
6.5.1.2 NAD+
-
 Escherichia coli
6.5.1.2 NAD+
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.5.1.2 0.000007
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000013
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000015
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00002
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
6.5.1.2 0.00002
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00002
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00002
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00002
-
 at pH 7.4 and 20°C Streptococcus pneumoniae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
6.5.1.2 0.000021
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000026
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00003
-
 at pH 7.4 and 20°C Haemophilus influenzae 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
6.5.1.2 0.000031
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000032
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000034
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
6.5.1.2 0.000036
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000037
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
6.5.1.2 0.00004
-
 at pH 7.4 and 20°C Staphylococcus aureus 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
6.5.1.2 0.000042
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000043
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000044
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000044
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000057
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000059
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000067
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000068
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.000077
-
 at pH 7.4 and 20°C Staphylococcus aureus 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
6.5.1.2 0.000077
-
 at pH 7.4 and 20°C Escherichia coli 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
6.5.1.2 0.000084
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0001
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00011
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00011
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00011
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00012
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00012
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00012
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00012
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00015
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00015
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00016
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00016
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00017
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00022
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00022
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00023
-
 at pH 7.4 and 20°C Escherichia coli 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
6.5.1.2 0.00026
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00027
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0003
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00031
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00031
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00034
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00035
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00039
-
 at pH 7.4 and 20°C Streptococcus pneumoniae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
6.5.1.2 0.0004
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00041
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00042
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00043
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00046
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00047
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00047
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00049
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0005
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0005
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00052
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00052
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00053
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00053
-
 at pH 7.4 and 20°C Staphylococcus aureus ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
6.5.1.2 0.00055
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00055
-
 at pH 7.4 and 20°C Staphylococcus aureus 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
6.5.1.2 0.00059
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00062
-
 at pH 7.4 and 20°C Haemophilus influenzae 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
6.5.1.2 0.00064
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00065
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00067
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00069
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00072
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00072
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00074
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00078
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00079
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00081
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00097
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00101
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0011
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0011
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00133
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0014
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00144
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0015
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0016
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00165
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0017
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0018
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0018
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0018
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00209
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0021
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00219
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.00224
-
 at pH 7.4 and 20°C Haemophilus influenzae 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
6.5.1.2 0.00275
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0037
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.005
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.0066
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01
-
 at pH 7.4 and 20°C Haemophilus influenzae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
6.5.1.2 0.013
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.013
-
 at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.01398
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.044
-
 at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.2
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.2
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.2
-
 at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
6.5.1.2 0.2
-
 at pH 7.4 and 20°C Staphylococcus aureus ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
6.5.1.2 0.2
-
 at pH 7.4 and 20°C Haemophilus influenzae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate