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Literature summary extracted from
- Mechanistic studies of the radical S-adenosyl-L-methionine enzyme 4-demethylwyosine synthase reveal the site of hydrogen atom abstraction (2015), Biochemistry, 54, 3569-3572 .
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.44 | N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine | Methanocaldococcus jannaschii | - |
4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O | - |
ir |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.44 | Methanocaldococcus jannaschii | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.3.44 | ammonium sulfate precipitation, HiTrap chealting column chromatography, and butyl Sepharose column chromatography | Methanocaldococcus jannaschii |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.44 | N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine | - |
Methanocaldococcus jannaschii | 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.3.44 | 4-demethylwyosine synthase | - |
Methanocaldococcus jannaschii |
| 4.1.3.44 | TYW1 | - |
Methanocaldococcus jannaschii |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.3.44 | S-adenosyl-L-methionine | - |
Methanocaldococcus jannaschii | |
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Release 2023.1 (January 2023)
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