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Literature summary extracted from
- Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD (2015), Biochem. Biophys. Res. Commun., 463, 235-240 .
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.2.1.8 | Drosophila melanogaster | P54353 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.2.1.8 | (cis)-Pro residue in phosphorylated protein PERIOD | phosphorylated isoforms of PERIOD serve as Dod substrates, leading to Dod-mediated conformational changes of PERIOD | Drosophila melanogaster | (trans)-Pro residue in phosphorylated protein PERIOD | - |
r |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.2.1.8 | Dod | - |
Drosophila melanogaster |
| 5.2.1.8 | Pin1 | - |
Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.2.1.8 | physiological function | overexpression lengthens the locomotor behavioral period. Dod associates preferentially with phosphorylated species of PERIOD, associated with the circadian clock machinery, which delays the phosphorylation-dependent degradation of PERIOD. PERIOD protein levels are higher in flies overexpressing Dod | Drosophila melanogaster |
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