EC Number | Cloned (Comment) | Organism |
---|---|---|
4.2.1.48 | - |
Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.48 | ADP | significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate | Mus musculus | |
4.2.1.48 | ATP | significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate | Mus musculus | |
4.2.1.48 | EDTA | - |
Mus musculus | |
4.2.1.48 | FAD | - |
Mus musculus | |
4.2.1.48 | FMN | - |
Mus musculus | |
4.2.1.48 | Mn2+ | completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.48 | 31.9 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.2.1.48 | mitochondrion | highly expressed in the mitochondrial matrix | Mus musculus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.48 | CaCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
4.2.1.48 | CuCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
4.2.1.48 | MgCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
4.2.1.48 | Mn2+ | completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
4.2.1.48 | ZnCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.2.1.48 | 146000 | - |
non-denaturing PAGE | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.48 | D-glutamate | Mus musculus | the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells | 5-oxo-D-proline + H2O | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.48 | Mus musculus | Q8BH86 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.2.1.48 | - |
Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.2.1.48 | heart | highly expressed in the mitochondrial matrix in the heart | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.48 | 5-oxo-D-proline + H2O | - |
Mus musculus | D-glutamate | - |
r | |
4.2.1.48 | D-glutamate | - |
Mus musculus | 5-oxo-D-proline + H2O | - |
r | |
4.2.1.48 | D-glutamate | the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells | Mus musculus | 5-oxo-D-proline + H2O | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.2.1.48 | dimer | 2 * 65874, calculated from sequence | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.48 | DGLUCY | - |
Mus musculus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.48 | 7.67 | - |
5-oxo-D-proline | pH 8.0, 37°C | Mus musculus | |
4.2.1.48 | 35.6 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.2.1.48 | 8 | - |
- |
Mus musculus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
4.2.1.48 | 6 | 8 | small but significant increase in activity occurrs between pH 6.0 to 8.0 | Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.2.1.48 | metabolism | disrupts D-glutamate and/or 5-oxo-D-proline levels, contributing to the onset and/or exacerbation of heart failure | Mus musculus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.48 | 1121 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |