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Literature summary extracted from

  • Rebbeor, J.; Connolly, G.; Henson, J.; Boyer, J.; Ballatori, N.
    ATP-dependent GSH and glutathione S-conjugate transport in skate liver Role of an Mrp functional homologue (2000), Am. J. Physiol., 279, G417-G425 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.3 digoxin 103% activity at 0.1 mM Leucoraja erinacea
7.6.2.3 N-7[(4-nitrobenzo-2-oxa-1,3-diazol)]-7beta-amino-3alpha,12alpha-dihydroxy-5beta-cholan-24-oyl-2-aminoethanesulfonate 110% activity at 0.l mM Leucoraja erinacea
7.6.2.3 p-aminohippuric acid 107% activity at 0.1 mM Leucoraja erinacea
7.6.2.3 taurocholate 103% activity at 0.1 mM Leucoraja erinacea

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.3 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid 10% residual activity at 1 mM Leucoraja erinacea
7.6.2.3 gramicidin D 97% residual activity at 0.01 mM Leucoraja erinacea
7.6.2.3 GSH 73% residual activity at 20 mM Leucoraja erinacea
7.6.2.3 GSSG 28% residual activity at 0.1 mM Leucoraja erinacea
7.6.2.3 leukotriene C4 9% residual activity at 0.1 mM Leucoraja erinacea
7.6.2.3 S-(2,4-dinitrophenyl)glutathione 64% residual activity at 0.0007 mM Leucoraja erinacea
7.6.2.3 Sulfobromophthalein 33% residual activity at 0.1 mM Leucoraja erinacea
7.6.2.3 vanadate 32% residual activity at 0.1 mM Leucoraja erinacea
7.6.2.3 verapamil 87% residual activity at 0.01 mM Leucoraja erinacea
7.6.2.3 vincristine 85% residual activity at 0.01 mM Leucoraja erinacea

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.3 0.032
-
 S-(2,4-dinitrophenyl)glutathione[side 1] at pH 7.5 and 20°C Leucoraja erinacea
7.6.2.3 0.4
-
 ATP with S-(2,4-dinitrophenyl)glutathione as cosubstrate, at pH 7.5 and 20°C Leucoraja erinacea
7.6.2.3 0.5
-
 ATP with S-glutathione as cosubstrate, at pH 7.5 and 20°C Leucoraja erinacea
7.6.2.3 12
-
 S-glutathione[side 1] at pH 7.5 and 20°C Leucoraja erinacea

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.3 plasma membrane
-
 Leucoraja erinacea 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.3 Mg2+ required in form of Mg-ATP Leucoraja erinacea

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Leucoraja erinacea Q8QG98
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 hepatocyte
-
 Leucoraja erinacea
-
7.6.2.3 liver
-
 Leucoraja erinacea
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Leucoraja erinacea ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-ethylglutathione[side 1]
-
 Leucoraja erinacea ADP + phosphate + S-ethylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-glutathione[side 1]
-
 Leucoraja erinacea ADP + phosphate + S-glutathione[side 2]
-
 ?
7.6.2.3 additional information no activity with adenylyl-imidodiphosphate Leucoraja erinacea ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.3 ? x * 180000, SDS-PAGE Leucoraja erinacea

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 MRP2
-
 Leucoraja erinacea

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.3 ATP
-
 Leucoraja erinacea