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Literature summary extracted from

  • Song, H.; Sung, H.P.; Tse, Y.S.; Jiang, M.; Guo, Z.
    Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues (2014), Acta Crystallogr. Sect. D, 70, 2959-2969 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.36 expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.3.36 in complex with 1-hydroxy-2-naphthoyl-CoA or salicylyl-CoA, hanging drop vapor diffusion method, using 0.3 M NaCl, 0.1 M Tris-HCl pH 8.0, 25% (w/v) PEG 3350 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA Mycobacterium tuberculosis
-
1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
?
4.1.3.36 o-succinylbenzoyl-CoA Mycobacterium tuberculosis H37Rv
-
1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.36 Mycobacterium tuberculosis P9WNP5
-
-
4.1.3.36 Mycobacterium tuberculosis H37Rv P9WNP5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.36 HiTrap chelating column chromatography and Sephacryl S-100 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA
-
Mycobacterium tuberculosis 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
?
4.1.3.36 o-succinylbenzoyl-CoA
-
Mycobacterium tuberculosis H37Rv 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
?

Subunits

EC Number Subunits Comment Organism
4.1.3.36 homohexamer x-ray crystallography Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
4.1.3.36 1,4-dihydroxy-2-naphthoyl coenzyme A synthase
-
Mycobacterium tuberculosis
4.1.3.36 DHNA-CoA synthase
-
Mycobacterium tuberculosis
4.1.3.36 MenB
-
Mycobacterium tuberculosis
4.1.3.36 Rv0548c
-
Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.3.36 additional information the enzyme is cofactor-free Mycobacterium tuberculosis