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Literature summary extracted from

  • Paparella, A.; Feng, J.; Blanco-Rodriguez, B.; Feng, Z.; Phetsang, W.; Blaskovich, M.; Cooper, M.; Booker, G.; Polyak, S.; Abell, A.
    A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase (2017), Tetrahedron, 74, 1175-1183 .
No PubMed abstract available

Application

EC Number Application Comment Organism
6.3.4.15 analysis fluorescent probe (4S)-4-[5-(1-[3-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propyl]-1H-1,2,3-triazol-4-yl)pentyl]tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one is synthesized by Bpl in vivo, accumulates in cytoplasm and can be used to gain insights into the mechanism of uptake, efflux and metabolism of BPL inhibitors Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.15 Staphylococcus aureus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.15 (4S)-4-(hept-6-yn-1-yl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one + 9-(4-azidobutyl)-9H-purin-6-amine i.e. reaction of acetylene derivative of biotin and an azide-functionalized adenine Staphylococcus aureus (4S)-4-(5-[1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl]pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
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6.3.4.15 (4S)-4-(hept-6-yn-1-yl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one + N-(3-azidopropyl)-7-nitro-2,1,3-benzoxadiazol-4-amine i.e. reaction of acetylene derivative of biotin and an azide-functionalied analogue of the fluorophore nitrobenzofurazan Staphylococcus aureus (4S)-4-[5-(1-[3-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propyl]-1H-1,2,3-triazol-4-yl)pentyl]tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
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