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Literature summary extracted from

  • Zhao, Y.; Tian, J.; Sui, S.; Yuan, X.; Chen, H.; Qu, C.; Du, Y.; Guo, L.; Du, H.
    Loss of succinyl-CoA synthase ADP-forming ? subunit disrupts mtDNA stability and mitochondrial dynamics in neurons (2017), Sci. Rep., 7, 7169 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.5 mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.5 ADP + phosphate + succinyl-CoA Mus musculus
-
ATP + succinate + CoA
-
r
6.2.1.5 ATP + succinate + CoA Mus musculus
-
ADP + phosphate + succinyl-CoA
-
r

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.5 Mus musculus Q9Z2I9 subunit beta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.5 neuron
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.5 ADP + phosphate + succinyl-CoA
-
Mus musculus ATP + succinate + CoA
-
r
6.2.1.5 ATP + succinate + CoA
-
Mus musculus ADP + phosphate + succinyl-CoA
-
r

Subunits

EC Number Subunits Comment Organism
6.2.1.5 ? x * 45000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.5 SCS A-beta
-
Mus musculus
6.2.1.5 SCS ADP-forming beta subunit
-
Mus musculus
6.2.1.5 succinyl-CoA synthase ADP-forming beta subunit
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.5 ATP
-
Mus musculus

General Information

EC Number General Information Comment Organism
6.2.1.5 malfunction enzyme deficiency induces severe mitochondrial dysfunction including lowered oxidative phosphorylation efficiency, increased mitochondrial superoxide production, and mitochondrial DNA depletion as well as aberrations of mitochondrial fusion and fission proteins, which eventually leads to neuronal stress Mus musculus